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Effect of polyethylene glycol molecular weight on cell growth behavior of polyvinyl alcohol/carboxymethyl cellulose/polyethylene glycol hydrogel
Journal of Applied Polymer Science ( IF 2.7 ) Pub Date : 2020-07-02 , DOI: 10.1002/app.49568 Ji‐Yeon Shin 1 , Deuk Yong Lee 1 , Bae‐Yeon Kim 2 , Jung In Yoon 3
Journal of Applied Polymer Science ( IF 2.7 ) Pub Date : 2020-07-02 , DOI: 10.1002/app.49568 Ji‐Yeon Shin 1 , Deuk Yong Lee 1 , Bae‐Yeon Kim 2 , Jung In Yoon 3
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Polyvinyl alcohol (PVA)/carboxymethyl cellulose (CMC)/polyethylene glycol (PEG) hydrogel scaffolds are synthesized using cyclic freezing/thawing and subsequent γ‐ray irradiation to evaluate the effect of the molecular weights of PEG (200, 400, 1,000, and 2,000) on strength and cell growth behavior of the hydrogels. As the PEG weight increases from 200 to 2,000, the compressive strength and the pore size decreases gradually from 58.0 ± 8.2 kPa to 17.7 ± 6.1 kPa and from 22.7 ± 3.9 μm to 8.5 ± 1.6 μm, respectively. However, the highest swelling rate is obtained for PVA/CMC/PEG400 hydrogels. The irradiated PVA/CMC/PEG400 hydrogels exhibit tailored properties of the swelling rate of 1,148 ± 34.0%, the compressive strength of 42.5 ± 6.6 kPa, the pore size of 14.6 ± 1.9 μm, and cell viability of 184%. In addition, the fastest L‐929 cell proliferation and growth with time, verified by the cell proliferation (0–48 hr) and the scratch assay (0–15 hr), was observed for the PVA/CMC/PEG400 hydrogels, indicating that they are highly suitable for potential wound dressings that require fast healing regeneration.
中文翻译：
聚乙二醇分子量对聚乙烯醇/羧甲基纤维素/聚乙二醇水凝胶细胞生长行为的影响
聚乙烯醇（PVA）/羧甲基纤维素（CMC）/聚乙二醇（PEG）水凝胶支架是使用循环冷冻/解冻以及随后的γ合成的进行射线照射以评估PEG分子量（200、400、1,000和2,000）对水凝胶强度和细胞生长行为的影响。随着PEG重量从200增加到2,000，抗压强度和孔径分别从58.0±8.2 kPa逐渐减小到17.7±6.1 kPa和从22.7±3.9μm减小到8.5±1.6μm。但是，PVA / CMC / PEG400水凝胶的溶胀率最高。辐照过的PVA / CMC / PEG400水凝胶具有特定的特性，溶胀率为1148±34.0％，抗压强度为42.5±6.6 kPa，孔径为14.6±1.9μm，细胞活力为184％。此外，对于PVA / CMC / PEG400水凝胶，观察到最快的L-929细胞随时间的增殖和生长，并通过细胞增殖（0-48小时）和刮擦试验（0-15小时）进行了验证，
更新日期：2020-07-02
中文翻译：
聚乙二醇分子量对聚乙烯醇/羧甲基纤维素/聚乙二醇水凝胶细胞生长行为的影响
聚乙烯醇（PVA）/羧甲基纤维素（CMC）/聚乙二醇（PEG）水凝胶支架是使用循环冷冻/解冻以及随后的γ合成的进行射线照射以评估PEG分子量（200、400、1,000和2,000）对水凝胶强度和细胞生长行为的影响。随着PEG重量从200增加到2,000，抗压强度和孔径分别从58.0±8.2 kPa逐渐减小到17.7±6.1 kPa和从22.7±3.9μm减小到8.5±1.6μm。但是，PVA / CMC / PEG400水凝胶的溶胀率最高。辐照过的PVA / CMC / PEG400水凝胶具有特定的特性，溶胀率为1148±34.0％，抗压强度为42.5±6.6 kPa，孔径为14.6±1.9μm，细胞活力为184％。此外，对于PVA / CMC / PEG400水凝胶，观察到最快的L-929细胞随时间的增殖和生长，并通过细胞增殖（0-48小时）和刮擦试验（0-15小时）进行了验证，
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