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The anterior insular cortex in the rat exerts an inhibitory influence over the loss of control of heroin intake and subsequent propensity to relapse.
European Journal of Neuroscience ( IF 2.7 ) Pub Date : 2020-07-03 , DOI: 10.1111/ejn.14889
Dhaval D Joshi 1 , Mickaël Puaud 1 , Maxime Fouyssac 1 , Aude Belin-Rauscent 1 , Barry Everitt 1 , David Belin 1
Affiliation  

The anterior insular cortex (AIC) has been implicated in addictive behaviour, including the loss of control over drug intake, craving and the propensity to relapse. Evidence suggests that the influence of the AIC on drug‐related behaviours is complex as in rats exposed to extended access to cocaine self‐administration, the AIC was shown to exert a state‐dependent, bidirectional influence on the development and expression of loss of control over drug intake, facilitating the latter but impairing the former. However, it is unclear whether this influence of the AIC is confined to stimulant drugs that have marked peripheral sympathomimetic and anxiogenic effects or whether it extends to other addictive drugs, such as opiates, that lack overt acute aversive peripheral effects. We investigated in outbred rats the effects of bilateral excitotoxic lesions of AIC induced both prior to or after long‐term exposure to extended access heroin self‐administration, on the development and maintenance of escalated heroin intake and the subsequent vulnerability to relapse following abstinence. Compared to sham surgeries, pre‐exposure AIC lesions had no effect on the development of loss of control over heroin intake, but lesions made after a history of escalated heroin intake potentiated escalation and also enhanced responding at relapse. These data show that the AIC inhibits or limits the loss of control over heroin intake and propensity to relapse, in marked contrast to its influence on the loss of control over cocaine intake.

中文翻译:

大鼠的前岛叶皮质对海洛因摄入控制的丧失和随后的复发倾向产生抑制作用。

前岛叶皮层 (AIC) 与成瘾行为有关,包括失去对药物摄入的控制、渴望和复发倾向。有证据表明,AIC 对药物相关行为的影响是复杂的,因为在暴露于长期可卡因自我给药的大鼠中,AIC 被证明对失控的发展和表达产生状态依赖性的双向影响过量服用药物,有利于后者而损害前者。然而,尚不清楚 AIC 的这种影响是否仅限于具有显着外周拟交感神经和焦虑作用的兴奋剂药物,或者它是否扩展到其他成瘾药物,如阿片类药物,这些药物缺乏明显的急性厌恶外周作用。我们在远交大鼠中研究了在长期接触海洛因自我给药之前或之后诱发的双侧 AIC 兴奋性毒性损伤对海洛因摄入量增加的发展和维持以及随后戒断后复发的易感性的影响。与假手术相比,暴露前 AIC 病变对海洛因摄入量失去控制的发展没有影响,但在海洛因摄入量增加的历史后产生的病变会加强升级,并且在复发时也增强了反应。这些数据表明,AIC 抑制或限制了对海洛因摄入的失控和复发倾向,与其对可卡因摄入失控的影响形成鲜明对比。关于不断增加的海洛因摄入量的发展和维持以及随后戒断后复发的脆弱性。与假手术相比,暴露前 AIC 病变对海洛因摄入量失去控制的发展没有影响,但在海洛因摄入量增加的历史后产生的病变会加强升级,并且在复发时也增强了反应。这些数据表明,AIC 抑制或限制了对海洛因摄入的失控和复发倾向,与其对可卡因摄入失控的影响形成鲜明对比。关于不断增加的海洛因摄入量的发展和维持以及随后戒断后复发的脆弱性。与假手术相比,暴露前 AIC 病变对海洛因摄入量失去控制的发展没有影响,但在海洛因摄入量增加的历史后产生的病变会加强升级,并且在复发时也增强了反应。这些数据表明,AIC 抑制或限制了对海洛因摄入的失控和复发倾向,与其对可卡因摄入失控的影响形成鲜明对比。但在海洛因摄入量增加的历史后造成的损害会加强升级,并增强复发时的反应。这些数据表明,AIC 抑制或限制了对海洛因摄入的失控和复发倾向,与其对可卡因摄入失控的影响形成鲜明对比。但在海洛因摄入量增加的历史后造成的损害会增强升级,并增强复发时的反应。这些数据表明,AIC 抑制或限制了对海洛因摄入的失控和复发倾向,与其对可卡因摄入失控的影响形成鲜明对比。
更新日期:2020-07-03
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