Mechanisms, Methods of Tracking and Applications of DNA Walkers: A Review.,ChemPhysChem

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Mechanisms, Methods of Tracking and Applications of DNA Walkers: A Review.
ChemPhysChem ( IF 2.3 ) Pub Date : 2020-08-18 , DOI: 10.1002/cphc.202000235
Julián Valero _{1,

2} , Marko Škugor ₂

Affiliation

In recent years, DNA nanotechnology expanded its scope from structural DNA nanoarchitecture towards designing dynamic and functional nanodevices. This progress has been evident in the development of an advanced class of DNA nanomachines, the so‐called DNA walkers. They represent an evolution of basic switching between distinctly defined states into continuous motion. Inspired by the naturally occurring walkers such as kinesin, research on DNA walkers has focused on developing new ways of powering them and investigating their walking mechanisms and advantages. New techniques allowing the visualization of walkers as single molecules and in real time have provided a deeper insight into their behavior and performance. The construction of novel DNA walkers bears great potential for applications in therapeutics, nanorobotics or computation. This review will cover the various examples and breakthrough designs of recently reported DNA walkers that pushed the limits of their performance. It will also mention the techniques that have been used to investigate walker nanosystems, as well as discuss the applications that have been explored so far.

中文翻译：

DNA Walker的机制，追踪方法和应用：综述。

近年来，DNA纳米技术将其范围从结构DNA纳米体系结构扩展到设计动态和功能性纳米设备。在先进的DNA纳米机器（所谓的DNA Walker）的开发中，这一进步是显而易见的。它们代表了从明确定义的状态到连续运动之间基本切换的演变。受诸如动力蛋白之类的自然助行器的启发，对DNA助行器的研究集中于开发为它们提供动力并研究其助行机制和优势的新方法。新技术允许将步行者可视化为单个分子并实时显示，从而使他们对行为和性能有了更深入的了解。新型DNA Walker的构建在治疗学，纳米机器人学或计算中具有广阔的应用前景。这篇综述将涵盖最近报道的DNA助步器的各种实例和突破性设计，这些助推器限制了其性能。它还将提及用于研究助行器纳米系统的技术，并讨论到目前为止已探索的应用程序。

更新日期：2020-08-18

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