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Efficient generation of thiolate sugars from glycosyl Bunte salts and its application to S-glycoside synthesis
Tetrahedron Letters ( IF 1.5 ) Pub Date : 2020-07-03 , DOI: 10.1016/j.tetlet.2020.152198
Yasuhiro Meguro , Masato Noguchi , Gefei Li , Shin-ichiro Shoda

A one-pot aqueous solution method for synthesis of S-glycoside derivatives has been developed. Firstly, unprotected sugars were converted into glycosyl Bunte salts from which thiolate sugars can be generated efficiently using Na2S. The subsequent addition reaction with vinyl compounds or organic halides has successfully been demonstrated, giving rise to the corresponding S-glycosides.



中文翻译:

由糖基邦特盐有效生成硫醇盐糖及其在S-糖苷合成中的应用

已经开发了用于合成S-糖苷衍生物的一锅法水溶液方法。首先,将未保护的糖转化为糖基邦特盐,使用Na 2 S可有效地生成巯基糖。随后成功地证明了与乙烯基化合物或有机卤化物的加成反应,生成了相应的S-糖苷。

更新日期:2020-07-18
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