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Generation of a human iPSC line CIBi007-A from a patient with young-onset Parkinson's disease carrying variants in PRKN and HTRA2.
Stem Cell Research ( IF 0.8 ) Pub Date : 2020-07-03 , DOI: 10.1016/j.scr.2020.101905 Yubo Yan 1 , Suihan Wu 2 , Lixiang Jiang 1 , Bo Yang 1 , Xuhui Chen 3 , Yuqing Liu 1 , Baorong Yu 1 , Jian Fu 1 , Jin Yu 2 , Hui Ning 2 , Meng Chu 1 , Jiayin Yang 4
中文翻译：
从携带 PRKN 和 HTRA2 变异的早发型帕金森病患者中产生人类 iPSC 系 CIBi007-A。
更新日期：2020-07-03
Stem Cell Research ( IF 0.8 ) Pub Date : 2020-07-03 , DOI: 10.1016/j.scr.2020.101905 Yubo Yan 1 , Suihan Wu 2 , Lixiang Jiang 1 , Bo Yang 1 , Xuhui Chen 3 , Yuqing Liu 1 , Baorong Yu 1 , Jian Fu 1 , Jin Yu 2 , Hui Ning 2 , Meng Chu 1 , Jiayin Yang 4
Affiliation
Variations in PRKN or HTRA2 are associated with Parkinson’s disease. We generated a human induced pluripotent stem cell (iPSC) line CIBi007-A from a patient with young-onset Parkinson’s disease (YOPD) who carried variants in PRKN and HTRA2. The generated iPSCs resembled human embryonic stem cells, expressed pluripotency markers, exhibited a normal karyotype, and could be differentiated into three germ layers in vitro. This line will be valuable for investigating disease mechanisms of YOPD and screening candidate drugs.
中文翻译：
从携带 PRKN 和 HTRA2 变异的早发型帕金森病患者中产生人类 iPSC 系 CIBi007-A。
PRKN 或 HTRA2 的变异与帕金森病有关。我们从一名携带 PRKN 和 HTRA2 变异的早发型帕金森病 (YOPD) 患者中产生了人类诱导多能干细胞 (iPSC) 系 CIBi007-A。生成的iPSC类似于人类胚胎干细胞，表达多能性标记，表现出正常的核型，并且可以在体外分化为三个胚层。该线对于研究 YOPD 的疾病机制和筛选候选药物具有重要价值。
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