Parkinson's disease (PD) is a disease of the human nervous system with an onset, in the sixth and seventh decades of the human life. Chiefly perceived as progressive degeneration of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc) with the ensued loss of dopamine in the striatum and the presence of Lewy bodies, consisting of α-synuclein agglomeration. In which the neuronal bridge between substantia nigra and striatum plays an advent role in the motor system. Dilapidation of these neurons results in dopamine depletion which in-turn makes hay to PD. Eventually, the etiology and pathogenesis of PD were still on a hike of dilemma. Traditional Chinese medicine (TCM), including Chinese herbal remedies, acupuncture, and manipulative therapies, is commonly used as an adjunctive therapy in different diseases, particularly neurological diseases, in Asian countries. Additionally, TCM might improve the prognoses and the quality of life of patients with PD because it induces less adverse drug reactions. The present review describes research on the various neuroprotective components and herbal extracts from herbal medicines in the context of addressing the effects of PD.

中文翻译：

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帕金森病是人类对草药疗法的信任的徒劳纠缠：综述

帕金森病（PD）是一种人类神经系统疾病，发病于人类六七十岁。主要被认为是黑质致密部 (SNpc) 中的多巴胺能 (DA) 神经元进行性变性，随后纹状体中多巴胺丢失，并出现由 α-突触核蛋白聚集体组成的路易体。其中黑质和纹状体之间的神经元桥在运动系统中发挥着重要作用。这些神经元的损坏会导致多巴胺耗竭，进而导致帕金森病。最终，PD的病因和发病机制仍然处于一个进退两难的境地。传统中医（TCM），包括中草药、针灸和手法疗法，在亚洲国家通常用作不同疾病，特别是神经系统疾病的辅助疗法。此外，中医可能会改善帕金森病患者的预后和生活质量，因为它引起的药物不良反应较少。本综述描述了在解决帕金森病影响的背景下对各种神经保护成分和草药提取物的研究。