The intervention effect of five Lactobacillus strains on the high-fat diet induced obese C57BL/6J mice was investigated. C57BL/6J mice were randomly divided into normal diet group (ND), high-fat diet group (HFD), HFD with Lactobacillus casei NCU011054 group (LC), HFD with Lactobacillus fermrntum NCU0413 group (LF), HFD with Lactobacillus acidophilus NCU433 group (LA), HFD with Lactobacillus rhamnosus NCU2217 group (LR), HFD with Lactobacillus paracasei NCU622 group (LP), with dosage of 10⁸ colony forming units (CFU)/ml. After intervention for 9 weeks, Lactobacillus strains had the potential ability to decrease body weight and Lee’s index, regulate lipid metabolism levels, and improve the morphology of adipose tissues. In addition, most of these Lactobacillus can significantly alter the levels of serum leptin (LEP) and adiponectin (ADPN). These results suggested that five Lactobacillus strains were able to alleviate obesity in mice induced by high-fat diet via relieving fat accumulation, lipid metabolism and regulating the content of leptin and adiponectin.

研究了五株乳酸杆菌菌株对高脂饮食诱导的肥胖C57BL / 6J小鼠的干预作用。C57BL / 6J小鼠随机分为正常饮食组（ND），高脂饮食组（HFD），HFD与干酪乳杆菌NCU011054组（LC），HFD与费氏乳杆菌NCU0413组（LF），HFD与嗜酸乳杆菌NCU433组（LA），鼠李糖乳杆菌NCU2217组（LR）的HFD，副干酪乳杆菌NCU622组（LP）的HFD ，剂量为10 ^8个菌落形成单位（CFU）/ ml。干预9周后，乳酸杆菌这些菌株具有降低体重和李氏指数，调节脂质代谢水平以及改善脂肪组织形态的潜在能力。此外，大多数这些乳酸杆菌可以显着改变血清瘦素（LEP）和脂联素（ADPN）的水平。这些结果表明，五种乳酸杆菌菌株能够通过减轻脂肪积累，脂质代谢和调节瘦素和脂联素的含量来减轻高脂饮食诱导的小鼠肥胖。