Sanghuangporus is a traditional medicine that has been used for nearly 2000 years in Asia. It has been found to enhance immunity and have anticancer properties. Some studies determined that Sanghuangporus polysaccharide can inhibit tumors in vitro, although the underlying mechanisms remain unknown. Therefore, the present study investigated the antitumor effects of polysaccharides from the fruiting body of S. vaninii and their associated mechanisms. Water-soluble S. vaninii polysaccharide (SVP) with a molecular weight of 3.156 × 10⁴ Da was isolated and found to be mainly composed of mannose, rhamnose, glucuronic acid, galacturonic acid, glucosamine, glucose, galactosamine, galactose, xylose, arabinose, and fucose in molar ratios of 1.63:0.04:0.36:0.03:0.13:8.39:0.08:1.08:0.25:1.07:0.40. SVP showed modest anti-proliferative activity against HeLa, SHG-44, SMMC-7721, and MCF-7 cells. Furthermore, it effectively regulated cell cycle, promoted apoptosis, and reduced the migratory and invasive capacities of MCF-7 cells. Mechanistically, SVP enhanced activation of p53-related genes and down-regulated MMP expression. These findings describe a potential natural polysaccharide for tumor therapy and a basis for the development of fungal polysaccharides as a type of health food.

Sanghuangporus是一种传统药物，在亚洲已经使用了近2000年。已经发现增强免疫力并具有抗癌特性。一些研究确定了桑黄孢子多糖可以在体外抑制肿瘤，尽管其潜在机制尚不清楚。因此，本研究调查了南美白葡萄球菌子实体多糖的抗肿瘤作用及其相关机制。水溶性沙门氏菌多糖（SVP），分子量为3.156×10 ⁴ 分离出Da，发现其主要成分为甘露糖，鼠李糖，葡萄糖醛酸，半乳糖醛酸，葡萄糖胺，葡萄糖，半乳糖胺，半乳糖，木糖，阿拉伯糖和岩藻糖，摩尔比为1.63：0.04：0.36：0.03：0.13：8.39： 0.08：1.08：0.25：1.07：0.40 SVP对HeLa，SHG-44，SMMC-7721和MCF-7细胞显示出适度的抗增殖活性。此外，它有效调节细胞周期，促进细胞凋亡，并降低MCF-7细胞的迁移和侵袭能力。从机制上讲，SVP增强了p53相关基因的激活并下调了MMP表达。这些发现描述了用于肿瘤治疗的潜在天然多糖，以及作为一种保健食品的真菌多糖的开发基础。