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Implications for glycosylated compounds and their anti-cancer effects.
International Journal of Biological Macromolecules ( IF 7.7 ) Pub Date : 2020-07-03 , DOI: 10.1016/j.ijbiomac.2020.06.281
Ramin Pourakbari 1 , Sanaz Mansouri Taher 2 , Bashir Mosayyebi 3 , Mohammad Hosein Ayoubi-Joshaghani 3 , Hamid Ahmadi 4 , Leili Aghebati-Maleki 5
Affiliation  

Glycosylated compounds are major secondary metabolites of plants, which have various therapeutic effects on human diseases, by acting as anti-cancer, antioxidant, and anti-inflammatory agents. Glycosylation increases stability, bioactivity, and solubility of compounds and improves their pharmacological properties. Two well-known examples of glycosylated compounds include cardiac and flavonoid, the anti-tumor activities of which have been emphasized by several studies. However, little is known about their role in the treatment or prevention of cancer. In this review, recent studies on anti-tumor properties of cardiac and flavonoid glycosides, and their mechanisms of action, have been investigated. More specifically, this review is aimed at focusing on the multifactorial properties of cardiac and flavonoid compounds as well as their correlation with signaling pathways in the treatment of cancer.



中文翻译:

对糖基化化合物及其抗癌作用的影响。

糖基化化合物是植物的主要次生代谢产物,通过充当抗癌剂,抗氧化剂和抗炎剂,对人类疾病具有多种治疗作用。糖基化增加了化合物的稳定性,生物活性和溶解度,并改善了它们的药理特性。糖基化化合物的两个众所周知的例子包括心脏和类黄酮,其抗肿瘤活性已被多项研究所强调。然而,关于它们在癌症的治疗或预防中的作用知之甚少。在这篇综述中,对心脏和类黄酮糖苷的抗肿瘤特性及其作用机理的最新研究已经进行了研究。进一步来说,

更新日期:2020-07-03
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