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Phytochemical analysis and biological evaluation of Lagochilus species from Uzbekistan
Industrial Crops and Products ( IF 5.6 ) Pub Date : 2020-07-02 , DOI: 10.1016/j.indcrop.2020.112715
Davlat Kh. Akramov , Markus Bacher , Stefan Böhmdorfer , Thomas Rosenau , Gokhan Zengin , Antje Potthast , Lutfun Nahar , Satyajit D. Sarker , Nilufar Z. Mamadalieva

The species of the genus Lagochilus (Lamiaceae) are widespread in Central, South-Central, and Eastern Asia. Some of these species are used for their medicinal and therapeutic effects, in particular as hemostatic, anti-inflammatory and anti-epileptic agents. A new iridoid, glucoside 7- cinnamoyllamalbide, along with known compounds lagochilin, 5-hydroxy-7,4′-dimethoxyflavone, daucosterol, β-sitosterol, 8-acetylharpagide were isolated from L. gypsaceus. The high-performance thin-layer chromatography (HPTLC) method was used to determine the chemical fingerprints of 7 different Lagochilus species (L. acutilobus, L. gypsaceus, L. inebrians, L. olgae, L. proskorjakovii, L. setulosus, L. vvedenskyi). Among the tested species, lagochilin content was highest in the endemic species L. inebrians collected from the Djizzakh region of Uzbekistan. In free radical scavenging and reducing power assays, L. inebrans and L. vvedenskyi exhibited the strongest abilities. Regarding cholinesterases, amylase and glucosidase inhibition abilities of the tested samples, 5-hydroxy-7,4′-dimethoxyflavone was the most active compound.



中文翻译:

乌兹别克斯坦Lagochilus物种的植物化学分析和生物学评估

属的物种兔唇(唇形科)是中亚,南亚,中亚和东亚普遍。这些物种中的某些出于其医学和治疗作用而使用,特别是用作止血剂,抗炎剂和抗癫痫药。从吉卜赛氏菌中分离出一种新的鸢尾碱,葡糖苷7-桂氨酰胺,以及已知的化合物lagochilin,5-羟基-7,4'-二甲氧基黄酮,胡萝卜素,β-谷甾醇,8-乙酰基庚酰胺。高性能薄层色谱法,使用(HPTLC)方法来确定的7个不同的化学指纹兔唇种(L. acutilobus,L. gypsaceusL.醉马L. olgaeL. proskorjakoviiL. setulosusL. vvedenskyi)。在被测物种中,从乌兹别克斯坦Djizzakh地区收集的地方性L. inebrians的拉古奇林含量最高。在自由基清除和降低功率的测定中,InebransL. vvedenskyi表现出最强的能力。关于测试样品的胆碱酯酶,淀粉酶和葡糖苷酶抑制能力,5-羟基-7,4'-二甲氧基黄酮是活性最高的化合物。

更新日期:2020-07-03
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