Detroit, Michigan, currently has the highest preterm birth (PTB) rate of large cities in the United States. Disproportionate exposure to ambient air pollutants, including particulate matter ≤2.5 μm (PM_2.5), PM ≤ 10 μm (PM₁₀), nitrogen dioxide (NO₂) and benzene, toluene, ethylbenzene, and xylenes (BTEX) may contribute to PTB. Our objective was to examine the association of airshed pollutants with PTB in Detroit, MI. The Geospatial Determinants of Health Outcomes Consortium (GeoDHOC) study collected air pollution measurements at 68 sites in Detroit in September 2008 and June 2009. GeoDHOC data were coupled with 2008–2010 Michigan Air Sampling Network measurements in Detroit to develop monthly ambient air pollution estimates at a spatial density of 300 m². Using delivery records from two urban hospitals, we established a retrospective birth cohort of births by Detroit women occurring from June 2008 to May 2010. Estimates of air pollutant exposure throughout pregnancy were assigned to maternal address at delivery. Our analytic sample size included 7961 births; 891 (11.2%) were PTB. After covariate adjustment, PM₁₀ (P = 0.003) and BTEX (P < 0.001), but not PM_2.5 (P = 0.376) or NO₂ (P = 0.582), were statistically significantly associated with PTB. In adjusted models, for every 5-unit increase in PM₁₀ there was a 1.21 times higher odds of PTB (95% CI 1.07, 1.38) and for every 5-unit increase in BTEX there was a 1.54 times higher odds of PTB (95% CI 1.25, 1.89). Consistent with previous studies, higher PM₁₀ was associated with PTB. We also found novel evidence that higher airshed BTEX is associated with PTB. Future studies confirming these associations and examining direct measures of exposure are needed.

密歇根州底特律目前是美国大城市中早产率最高的城市。不成比例地暴露于环境空气污染物，包括颗粒物≤2.5 μm (PM _2.5 )、PM ≤ 10 μm (PM ₁₀ )、二氧化氮 (NO ₂ ) 和苯、甲苯、乙苯和二甲苯 (BTEX) 可能导致 PTB。我们的目标是在密歇根州底特律检查空气流域污染物与 PTB 的关系。健康结果的地理空间决定因素联盟 (GeoDHOC) 研究在 2008 年 9 月和 2009 年 6 月收集了底特律 68 个地点的空气污染测量值。GeoDHOC 数据与底特律 2008-2010 年密歇根空气采样网络测量值相结合，以制定每月环境空气污染估计值300 m的空间密度² . 利用两家城市医院的分娩记录，我们建立了 2008 年 6 月至 2010 年 5 月底特律妇女出生的回顾性出生队列。整个怀孕期间空气污染物暴露的估计值被分配到分娩时的产妇地址。我们的分析样本量包括 7961 名新生儿；891 (11.2%) 是 PTB。协变量调整后，PM ₁₀ (P = 0.003) 和 BTEX (P < 0.001)，但不是 PM _2.5 (P = 0.376) 或 NO ₂ (P = 0.582)，与 PTB 有统计学显着相关性。在调整后的模型中，PM _{10每增加 5 个单位}PTB 的几率高出 1.21 倍（95% CI 1.07, 1.38），BTEX 每增加 5 个单位，PTB 的几率就会高出 1.54 倍（95% CI 1.25, 1.89）。与之前的研究一致，较高的 PM ₁₀与 PTB 相关。我们还发现新的证据表明较高的空气流域 BTEX 与 PTB 相关。未来的研究需要证实这些关联并检查暴露的直接测量。