Abstract The integration of different environmental cues and the harmonization of proper responses require molecular communication at different levels. Enzymes belonging to the large superfamily of 2-oxoglutarate-dependent dioxygenases (2-ODDs) use for their catalytic activity different cofactors, including molecular oxygen, 2-oxoglutarate, and ascorbic acid (ASC). In plants, 2-ODDs are involved in the synthesis of hydroxyproline (largely present in cell wall proteins), gibberellins, ethylene, zeaxanthin, and many more relevant molecules. In addition, 2-ODDs operating in the epigenetic control of gene expression by regulating cytosine and histone methylation have been recently identified in both animals and plants. It is here hypothesized that each of the cofactors required for the complex catalytic mechanism of 2-ODDs provides specific molecular information. Such information is integrated by 2-ODDs, which in turn regulate the synthesis of information-bearing metabolites (e.g. hormones), and control epigenetic processes. The evolutionary success of the catalytic mechanism shared by 2-ODDs is possibly related to the parallel activation of different biosynthetic pathways.

中文翻译：

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抗坏血酸是整合 2-酮戊二酸依赖性双加氧酶活性的关键信号分子吗？转变范式

摘要 不同环境线索的整合和适当反应的协调需要不同层次的分子通讯。属于 2-酮戊二酸依赖性双加氧酶 (2-ODD) 大超家族的酶使用不同的辅助因子来发挥其催化活性，包括分子氧、2-酮戊二酸和抗坏血酸 (ASC)。在植物中，2-ODDs 参与羟脯氨酸（主要存在于细胞壁蛋白中）、赤霉素、乙烯、玉米黄质和更多相关分子的合成。此外，最近在动物和植物中发现了通过调节胞嘧啶和组蛋白甲基化在基因表达的表观遗传控制中起作用的 2-ODD。这里假设 2-ODD 的复杂催化机制所需的每个辅因子都提供特定的分子信息。此类信息由 2-ODD 整合，进而调节携带信息的代谢物（例如激素）的合成，并控制表观遗传过程。2-ODD 共享催化机制的进化成功可能与不同生物合成途径的平行激活有关。