As an effective platform to deliver therapeutic drugs into tumors, nanoparticles (NPs) have shown great potential for cancer therapy. However, the tumor microenvironment (TME) contains diverse barriers to the transport of NPs, particularly the dense extracellular matrix (ECM). Thus, engineering the tumor ECM is a promising way to improve drug delivery by degrading existing ECM and/or blocking ECM synthesis. In this review, we present the state-of-the-art advances in engineering the tumor ECM to improve the therapeutic efficacy of NPs, and highlight their advantages and limitations.

中文翻译：

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工程细胞外基质以改善癌症治疗的药物输送。

作为将治疗药物输送到肿瘤中的有效平台，纳米颗粒 (NPs) 已显示出巨大的癌症治疗潜力。然而，肿瘤微环境 (TME) 包含多种阻碍 NPs 运输的障碍，尤其是致密的细胞外基质 (ECM)。因此，改造肿瘤 ECM 是通过降解现有 ECM 和/或阻断 ECM 合成来改善药物输送的一种有前途的方法。在这篇综述中，我们展示了在工程化肿瘤 ECM 以提高 NPs 治疗效果方面的最新进展，并强调了它们的优点和局限性。