Malaria remains as one of the major public health problems worldwide. About 228 million cases occurred in 2018 only, with Africa bearing about 93% of the cases. Asymptomatic population carrying the various forms of the parasite Plasmodium in endemic areas plays an important role in the spread of the disease. To tackle this battle, more sensitive and precise detection kits for malaria are crucial to better control the number of new malaria cases. In this review, we not only discuss some of the available approaches to rapidly detect new malaria cases in endemic areas but also shed light on parallel problems that may affect the detection of individuals infected with the parasite, covering kelch 13 mutation, glucose 6-phosphate dehydrogenase deficiency, and hemoglobin disorders. Available approaches for malaria detection covered in this review are focused on point-of-care tests, including portable polymerase chain reaction and aptamers.

疟疾仍然是全世界主要的公共卫生问题之一。仅在2018年就发生了约2.28亿例病例，其中非洲约占93％。在流行地区，无症状人群携带各种形式的寄生虫疟原虫，在疾病传播中起重要作用。为了应对这场斗争，更灵敏，更精确的疟疾检测套件对于更好地控制新的疟疾病例至关重要。在这篇综述中，我们不仅讨论了一些在流行地区迅速发现新的疟疾病例的可用方法，而且还揭示了可能影响发现寄生虫的平行问题（包括海藻）13突变，6-磷酸葡萄糖脱氢酶缺乏症和血红蛋白异常。这篇综述中涵盖的疟疾检测可用方法主要针对即时检测，包括便携式聚合酶链反应和适体。