Intermediate filaments (IFs), together with actin and microtubules, constitute the cytoskeleton and regulate essential biological processes including cell migration. Despite the well-described changes in the composition of IFs in migrating cells, the mechanism by which these changes may contribute to cell migration remains elusive. Recent studies show that IFs control cell migration by impacting the actomyosin machinery. This review discusses how the unique physical properties of IFs, the interplay between IFs and the actomyosin network, and the connection of IFs with cell adhesive structures participate in cell migration. We highlight the biochemical and mechanical mechanisms by which IFs control actomyosin-generated forces to influence migration speed and contribute to nuclear integrity and cell resilience to compressive forces in 2D, as well as in confined 3D migration.

中间丝（IF）与肌动蛋白和微管一起构成细胞骨架，并调节包括细胞迁移在内的基本生物学过程。尽管迁移细胞中IF的组成发生了众所周知的变化，但这些变化可能有助于细胞迁移的机制仍然不清楚。最近的研究表明，中频通过影响放线菌素机制来控制细胞迁移。这篇综述讨论了IF的独特物理特性，IF与放线菌素网络之间的相互作用以及IF与细胞黏附结构的连接如何参与细胞迁移。我们重点介绍了生物化学和机械机制，IFs通过这些生物化学和机械机制来控制肌动球蛋白产生的力，从而影响迁移速度并有助于核完整性和细胞对2D压缩力的弹性，