OBJECTIVE Speech deficits are common in Parkinson's disease, and behavioural findings suggest that the deficits may be due to impaired monitoring of self-produced speech. The neural mechanisms of speech deficits are not well understood. We examined a well-documented electrophysiological correlate of speech self-monitoring in patients with Parkinson's disease and control participants. METHODS We measured evoked electroencephalographic responses to self-produced and passively heard sounds (/a/ phonemes) in age-matched controls (N = 18), and Parkinson's disease patients who had minor speech impairment, but reported subjectively experiencing no speech deficits (N = 17). RESULTS During speaking, auditory evoked activity 100 ms after phonation (N1 wave) was less suppressed in Parkinson's disease than controls when compared to the activity evoked by passively heard phonemes. This difference between the groups was driven by increased amplitudes to self-produced phonemes, and reduced amplitudes passively heard phonemes in Parkinson's disease. CONCLUSIONS The finding indicates that auditory evoked activity is abnormally modulated during speech in Parkinson's patients who do not subjectively notice speech impairment. This mechanism could play a role in producing speech deficits in as the disease progresses. SIGNIFICANCE Our study is the first to show abnormal early auditory electrophysiological correlates of monitoring speech in Parkinson's disease patients.

中文翻译：

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帕金森病自发言语监测的缺陷

目的 言语障碍在帕金森病中很常见，行为研究结果表明，这种障碍可能是由于对自发言语的监控受损。言语缺陷的神经机制尚不清楚。我们检查了帕金森病患者和对照组参与者言语自我监测的电生理相关性。方法 我们测量了年龄匹配的对照组（N = 18）和患有轻微言语障碍但主观上没有言语缺陷的帕金森病患者（N = 18）对自发和被动听到的声音（/a/音素）的诱发脑电图反应（N = 17）。结果 在说话过程中，发声后 100 ms 的听觉诱发活动（N1 波）在帕金森患者中受到的抑制较少 与被动听到的音素引起的活动相比，s 的疾病比对照组多。两组之间的这种差异是由自产音素的振幅增加以及帕金森氏病中被动听到的音素振幅降低所致。结论 该发现表明，在主观上没有注意到言语障碍的帕金森病患者的言语过程中，听觉诱发活动受到异常调节。随着疾病的进展，这种机制可能在产生言语缺陷方面发挥作用。意义我们的研究首次显示了帕金森病患者监测言语的异常早期听觉电生理相关性。和减少振幅被动听到帕金森病中的音素。结论 该发现表明，在主观上没有注意到言语障碍的帕金森病患者的言语过程中，听觉诱发活动受到异常调节。随着疾病的进展，这种机制可能在产生言语缺陷方面发挥作用。意义我们的研究首次显示了帕金森病患者监测言语的异常早期听觉电生理相关性。和减少振幅被动听到帕金森病中的音素。结论 该发现表明，在主观上没有注意到言语障碍的帕金森病患者的言语过程中，听觉诱发活动受到异常调节。随着疾病的进展，这种机制可能在产生言语缺陷方面发挥作用。意义我们的研究首次显示了帕金森病患者监测言语的异常早期听觉电生理相关性。