Clostridium perfringens is ubiquitous in the environment and the gastrointestinal tract of warm-blooded animals. While part of the gut microbiome, abnormal growth of C. perfringens causes histotoxic, neurologic, and enteric diseases in a variety of animal species, including humans, due to the production of toxins. There is extremely limited information on C. perfringens infection in non-human primates. Presently, 10 strains were successfully isolated from 126 monkeys and confirmed by molecular and biochemical analyses. All isolates were genotype A based on molecular analysis. Alpha toxin was identified in all isolates. Beta 2 toxin was detected in only three isolates. No other toxins, including enterotoxin, beta, iota, epsilon, and net B toxin, were identified in any isolate. All isolates were highly susceptible to β-lactam antibiotics. Double hemolysis and lecithinase activity were commonly observed in all strains. Biofilm formation, which can increase antibiotic resistance, was identified in 90% of the isolates. The data are the first report the prevalence and characteristics of C. perfringens isolated from captive cynomolgus monkeys.

产气荚膜梭菌在环境和温血动物的胃肠道中普遍存在。虽然是肠道微生物组的一部分，但产气荚膜梭菌的异常生长会由于产生毒素而导致包括人类在内的多种动物物种发生组织毒性，神经系统和肠道疾病。关于产气荚膜梭菌的信息非常有限在非人类灵长类动物中感染。目前，已从126只猴子中成功分离出10株，并通过分子和生化分析进行了确认。基于分子分析，所有分离物均为基因型A。在所有分离物中均鉴定出α毒素。仅在三个分离物中检测到Beta 2毒素。在任何分离物中均未鉴定出其他毒素，包括肠毒素，β，iota，ε和净B毒素。所有分离株都对β-内酰胺类抗生素高度敏感。在所有菌株中通常观察到双重溶血和卵磷脂酶活性。在90％的分离物中鉴定出可增加抗生素抗性的生物膜形成。数据是首次报道了从圈养食蟹猴分离的产气荚膜梭菌的流行情况和特征。