Acta Biomaterialia ( IF 9.4 ) Pub Date : 2020-07-03 , DOI: 10.1016/j.actbio.2020.06.038 Yueqi Zhao 1 , Ruikang Tang 2
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Biomineralization, a bio-organism controlled mineral formation process, plays an important role in linking biological organisms and mineral materials in nature. Inspired by biomineralization, biomimetic mineralization is used as a bridge tool to integrate biological organisms and functional materials together, which can be beneficial for the development of diversified functional organism-material hybrids. In this review, recent progresses on the techniques of biomimetic mineralization for organism-material combinations are summarized and discussed. Based upon these techniques, the preparations and applications of virus-, prokaryotes-, and eukaryotes-material hybrids have been presented and they demonstrate the great potentials in the fields of vaccine improvement, cell protection, energy production, environmental and biomedical treatments, etc. We suggest that more researches about functional organism and material combination with more biocompatible techniques should be developed to improve the design and applications of specific organism-material hybrids. These rationally designed organism-material hybrids will shed light on the production of “live materials” with more advanced functions in future.
Statement of Significance
This review summaries the recent attempts on improving biological organisms by their integrations with functional materials, which can be achieved by biomimetic mineralization as the combination tool. The integrated materials, as the artificial shells or organelles, confer diversified functions on the enclosed organisms. The successful constructions of various virus-, prokaryotes-, and eukaryotes-material hybrids have demonstrated the great potentials of the material incorporation strategy in vaccine development, cancer treatment, biological photosynthesis and environment protection etc. The suggested challenges and perspectives indicate more inspirations for the future development of organism-material hybrids.
中文翻译：
通过仿生矿化改善生物体：一种用于生物修饰的材料掺入策略。
生物矿化是生物有机体控制的矿物形成过程，在将生物有机体与自然界的矿物材料联系起来方面发挥着重要作用。受生物矿化的启发，仿生矿化被用作将生物有机体和功能性材料整合在一起的桥梁工具，这可能对多种功能性生物体-材料杂种的发展有益。在这篇综述中，总结并讨论了仿生矿物质用于生物材料组合的技术的最新进展。基于这些技术，已经提出了病毒，原核生物和真核生物材料杂交体的制备和应用，它们在疫苗改良，细胞保护，能源生产，环境和生物医学治疗等领域展示了巨大的潜力，等。我们建议应开展更多有关功能性有机物和材料结合以及更多生物相容性技术的研究，以改善特定生物体-材料杂种的设计和应用。这些经过合理设计的生物材料混合体将为将来生产具有更高级功能的“活物质”提供启示。
重要声明
这篇综述总结了最近通过与功能性材料整合来改善生物体的尝试，这可以通过仿生矿化作为组合工具来实现。集成的材料（如人造壳或细胞器）赋予封闭生物以多种功能。各种病毒，原核生物和真核生物材料杂种的成功构建证明了材料掺入策略在疫苗开发，癌症治疗，生物光合作用和环境保护等方面的巨大潜力。建议的挑战和观点为该技术带来了更多的启发。生物材料杂交的未来发展。
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