Syndrome of oculopalatal tremor (OPT) causes pendular nystagmus of the eyes and its disabling consequence on the visual system. Classic pharmacotherapeutic studies revealed reduction in the eye velocity of the oscillatory waveforms. Subjective improvement in vision, however, remains out of proportionately low. Elegant models depicting quasi-sinusoidal coarse oscillations of the eyes highlighted two distinct oscillators; one at the inferior olive causing primary 2 Hz oscillations, while the second, independent oscillator, at the cerebellum adding the randomness to the waveform. Here we examined whether pharmacotherapy affects the randomness of the oscillatory waveform. Horizontal, vertical, and torsional angular eye positions were measured independently from both eyes as six subjects with OPT directed gaze toward a straight-ahead target. The measurements were performed before administration of alpha-2-delta calcium channel blocker (gabapentin) or NMDA receptor antagonist (memantine) and after the subjects were treated with each of these drugs for at least 8 days. Amplitude and velocity of eye oscillations were reduced by gabapentin and memantine, but there was an increase in the waveform randomness. We found that the increase in randomness was proportionate to the amount of reduction in the waveform velocity or amplitude. Hierarchical clustering revealed distinct patterns of oscillatory waveforms, with each subject belonging to a specific cluster group. The pharmacotherapy changed the waveform clustering pattern of the waveform in each subject. We conclude that in addition to incomplete resolution of the oscillation intensity, increased randomness could be one of the reasons why there is not enough clinical difference in the patients’ visual quality.

眼腭震颤 (OPT) 综合征会导致眼睛的摆动性眼球震颤及其对视觉系统的致残后果。经典的药物治疗研究揭示了振荡波形的眼速度降低。然而，视力的主观改善仍然不成比例。描绘眼睛准正弦粗略振荡的优雅模型突出显示了两个不同的振荡器；一个在下橄榄引起主要 2 Hz 振荡，而第二个独立振荡器在小脑，为波形增加了随机性。在这里，我们检查了药物治疗是否会影响振荡波形的随机性。水平、垂直和扭转角度的眼睛位置是独立于双眼测量的，作为六名受试者，OPT 直接注视着一个正前方的目标。测量是在使用 α-2-δ 钙通道阻滞剂（加巴喷丁）或 NMDA 受体拮抗剂（美金刚）之前和受试者用这些药物中的每一种治疗至少 8 天之后进行的。加巴喷丁和美金刚降低了眼睛振荡的幅度和速度，但波形随机性增加了。我们发现随机性的增加与波形速度或幅度的减少量成正比。分层聚类揭示了振荡波形的不同模式，每个受试者属于一个特定的聚类组。药物治疗改变了每个受试者中波形的波形聚类模式。我们得出结论，除了振荡强度的不完整分辨率之外，