From clinical point of view, it is necessary to develop a reliable detection method of Ledipasvir drug which is a promising medication regimen to treat HCV infection. So, an electrochemical sensor based on NiO nano-flakes (NiO NFs) and activated charcoal (ACH) as natural carbon material was developed for this propose. The characterization of ACH revealed its nano-structure. Its crystallites are composed of 3–8 parallel plane layers of graphite (graphene like structures) with interlayer distance and crystallite size of 0.37 and 0.90 nm, respectively. Highly-crystallized pure NiO NFs with crystallite size of 14 nm and inter-planar distance of 0.21 nm were prepared. ACH/CPE afforded 2-fold enhancement in the electrochemical response towards oxidation of ledipasvir exceeds graphene/CPE. ACH’s high surface area, porous structure and edge-plane-like defective sites of its graphene platelets result in good adsorptive and electron transfer efficiency towards ledipasvir. Among bare CPE, ...

中文翻译：

---

利用合成的NiO纳米薄片和天然活性炭（石墨烯的替代品）的协同效益作为伏安法测定慢性丙型肝炎病毒抑制剂Ledipasvir的新型平台

从临床角度来看，有必要开发一种可靠的Ledipasvir药物检测方法，该方法是治疗HCV感染的有前途的药物治疗方案。因此，为此提出了一种基于NiO纳米薄片（NiO NFs）和活性炭（ACH）作为天然碳材料的电化学传感器。ACH的表征揭示了其纳米结构。它的微晶由3-8个平行的石墨平行层（石墨烯状结构）组成，层间距离和微晶尺寸分别为0.37和0.90 nm。制备了微晶尺寸为14 nm，晶面间距为0.21 nm的高度结晶的纯NiO NF。ACH / CPE提供的针对Lepidasvir氧化的电化学响应增强了2倍，超过了石墨烯/ CPE。ACH的高表面积，石墨烯血小板的多孔结构和边缘平面状缺陷位点导致对ledipasvir的良好吸附和电子转移效率。在裸机CPE中，...