Vitamin C is one of the most important micronutrient required for various physiological roles in the human system. Evidences suggest that there is an inadequate status of vitamin C in diabetes mellitus. The objectives of this study is to understand the prevalence of vitamin C deficiency in established type II diabetes mellitus patients and to study the correlation between various variables of diabetes mellitus with serum vitamin C levels. A prospective cross-sectional study to assess the prevalence of vitamin C deficiency was carried out in diabetes patients. Fasting blood sugar levels, glycated hemoglobin, serum malondialdehyde levels, and lipid profile levels were correlated with serum vitamin C levels. The prevalence rate of hypovitaminosis C is found to be 55.13% among the enrolled patients. There is a significant increase in the systolic blood pressure levels in patients with inadequate as well as deficient vitamin C levels (p < 0.05). Inverse relationship exists between fasting blood sugar and vitamin C levels (p < 0.001). Similarly total cholesterol levels were also inversely related to the vitamin C levels (p = 0.0031). Body mass index, glycated hemoglobin, and fasting blood sugar levels are important predictors of vitamin C deficiencies. Vitamin C deficiency is well established among diabetes mellitus patients. Deficiency of vitamin C levels has an impact on the serum malondialdehyde levels suggesting increased oxidative stress. The higher oxidative stress would have led to increase in glycated hemoglobin. Further research must be carried out to understand the beneficial effects of vitamin C supplementation in diabetes mellitus.

中文翻译：

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糖尿病中维生素C状态的关联：维生素C缺乏症的患病率和预测因素

维生素C是人体系统中各种生理作用所需的最重要的微量营养素之一。有证据表明，糖尿病中维生素C的状态不足。这项研究的目的是了解已确定的II型糖尿病患者中维生素C缺乏症的患病率，并研究各种糖尿病变量与血清维生素C水平之间的相关性。在糖尿病患者中进行了一项前瞻性横断面研究，以评估维生素C缺乏症的患病率。空腹血糖水平，糖化血红蛋白，血清丙二醛水平和脂质分布水平与血清​​维生素C水平相关。登记的患者中维生素C缺乏症的患病率为55.13％。维生素C水平不足和不足的患者的收缩压水平显着增加（p <0.05）。空腹血糖与维生素C水平之间存在反比关系（p <0.001）。同样，总胆固醇水平也与维生素C水平成反比关系（p = 0.0031）。体重指数，糖化血红蛋白和空腹血糖水平是维生素C缺乏症的重要预测指标。维生素C缺乏症在糖尿病患者中已得到充分证实。维生素C含量不足会对血清丙二醛含量产生影响，表明氧化应激增加。较高的氧化应激会导致糖化血红蛋白增加。