Dyslipidemia is a well-known risk factor for cardiovascular disease (CVD). Recently, atherogenic index of plasma (AIP) has been proposed as a novel predictive marker for CVD, and few cross sectional studies have demonstrated a relationship between AIP and coronary artery disease. The present study investigated the association between AIP and the progression of coronary artery calcification (CAC) in Korean adults without CVD. A total of 1124 participants who had undergone CAC measurement at least twice by multi-detector computed tomography (CT) at a health check-up center were enrolled. Their anthropometric measurements and various cardiovascular risk factors were assessed. AIP was defined as the base 10 logarithm of the ratio of the concentration of triglyceride (TG) to high-density lipoprotein-cholesterol (HDL-C). CAC progression was defined as either incident CAC in a CAC-free population at baseline, or an increase of ≥2.5 units between the square roots of the baseline and follow-up coronary artery calcium scores (CACS) in subjects with detectable CAC at baseline. CAC progression was observed in 290 subjects (25.8%) during the mean follow-up of 4.2 years. All subjects were stratified into three groups according to AIP. There were significant differences in cardiovascular parameters among groups at baseline. The follow-up CAC and the incidence of CAC progression increased gradually with rising AIP tertiles. In logistic regression analysis, the odds ratio for CAC progression was 2.27 when comparing the highest to the lowest tertile of AIP (95% CI: 1.61–3.19; P for trend < 0.01). However, this association was attenuated after adjustment for multiple risk factors (P for trend = 0.67). There is a significant correlation between AIP and the progression of CAC in subjects without CVD. Although AIP was not an independent predictor of CAC progression, AIP should be considered when estimating the current as well as future CVD risk, along with other traditional risk factors.

中文翻译：

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血浆动脉粥样化指数与韩国成年人冠状动脉钙化进展之间的关系。

血脂异常是心血管疾病（CVD）的众所周知的危险因素。最近，血浆动脉粥样硬化指数（AIP）已被提议作为CVD的一种新型预测标志物，很少有截面研究证明AIP与冠状动脉疾病之间的关系。本研究调查了在没有CVD的韩国成年人中AIP与冠状动脉钙化（CAC）进展之间的关系。总共有1124名参与者在健康检查中心接受了两次多计算机断层扫描（CT）的CAC测量，至少两次。他们的人体测量和各种心血管危险因素进行了评估。AIP定义为甘油三酸酯（TG）与高密度脂蛋白胆固醇（HDL-C）浓度之比的10个对数。CAC进展被定义为基线时无CAC的人群中发生的CAC，或者基线时可检测到CAC的受试者的基线平方根与随访冠状动脉钙分数（CACS）之间增加≥2.5个单位。在4.2年的平均随访期间，对290名受试者（25.8％）观察到了CAC进展。根据AIP，将所有受试者分为三组。基线时各组之间的心血管参数存在显着差异。随着AIP三分位数的增加，随访CAC和CAC进展的发生率逐渐增加。在逻辑回归分析中，当比较AIP的最高和最低三分位数时，CAC进展的优势比为2.27（95％CI：1.61-3.19；趋势<0.01的P）。然而，在调整了多个风险因素后，这种关联性减弱了（趋势的P = 0.67）。在没有CVD的受试者中，AIP与CAC的进展之间存在显着的相关性。尽管AIP并不是CAC进展的独立预测因素，但在评估当前和未来的CVD风险以及其他传统风险因素时，应考虑AIP。