Children with leukemia treated with methotrexate (MTX) may develop MTX-induced leukoencephalopathy, which can present as seizures or focal neurological deficits. However, the precise pathophysiology has not been fully elucidated. Differences in cytokine/chemokine profiles in cerebrospinal fluid (CSF) between children with MTX-induced leukoencephalopathy and those with posterior reversible encephalopathy syndrome (PRES), an acute neurological condition associated with hypertension, were investigated. Interleukin (IL)-1β, 2, 4, 5, 6, 7, 8, 10, 12, 13, and 17, tumor necrosis factor-alpha, interferon-gamma, granulocyte monocyte colony-stimulating factor, granulocyte colony-stimulating factor, macrophage inflammatory protein-1β, and monocyte chemoattractant protein-1 concentrations were measured in CSF supernatants from 3 children with acute leukemia with MTX-induced leukoencephalopathy, 3 children with acute leukemia with PRES, 6 children with acute leukemia without neurological complications, and 8 children with acute encephalopathy. CSF IL-6 concentrations were higher in children with MTX-induced leukoencephalopathy than in children with acute leukemia with PRES, with acute leukemia without neurological complications, and with acute encephalopathy. We concluded that IL-6 may be involved in the pathogenesis of MTX-induced leukoencephalopathy.

中文翻译：

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白介素6介导的炎症可能引起甲氨蝶呤诱导的白质脑病。

甲氨蝶呤（MTX）治疗的白血病患儿可能会发展成MTX引起的白质脑病，表现为癫痫发作或局灶性神经功能缺损。但是，尚未完全阐明确切的病理生理学。研究了MTX诱发的白质脑病患儿与后可逆性脑病综合征（PRES）（一种与高血压相关的急性神经系统疾病）患儿的脑脊液（CSF）细胞因子/趋化因子谱的差异。白介素（IL）-1β，2、4、5、6、7、8、10、12、13和17，肿瘤坏死因子-α，干扰素-γ，粒细胞单核细胞集落刺激因子，粒细胞集落刺激因子，巨噬细胞炎性蛋白1β，在3例MTX引起的白细胞性脑病的急性白血病，3例PRES的急性白血病，6例无神经系统并发症的急性白血病和8例急性脑病的儿童的CSF上清液中检测了CSF和单核细胞趋化蛋白1的浓度。MTX致白细胞脑病患儿的CSF IL-6浓度高于PRES急性白血病，无神经系统并发症的急性白血病和急性脑病的患儿。我们得出结论，IL-6可能参与了MTX引起的白质脑病的发病机理。MTX致白细胞脑病患儿的CSF IL-6浓度高于PRES急性白血病，无神经系统并发症的急性白血病和急性脑病的患儿。我们得出结论，IL-6可能参与了MTX引起的白质脑病的发病机理。MTX致白细胞脑病患儿的CSF IL-6浓度高于PRES急性白血病，无神经系统并发症的急性白血病和急性脑病的患儿。我们得出结论，IL-6可能参与了MTX引起的白质脑病的发病机理。