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FeCl3-Mediated Synthesis of 2-(Trifluoromethyl)quinazolin-4(3H)-ones from Isatins and Trifluoroacetimidoyl Chlorides.
Organic Letters ( IF 4.9 ) Pub Date : 2020-07-01 , DOI: 10.1021/acs.orglett.0c01927 Le-Cheng Wang 1 , Shiying Du 1 , Zhengkai Chen 1 , Xiao-Feng Wu 1, 2
Organic Letters ( IF 4.9 ) Pub Date : 2020-07-01 , DOI: 10.1021/acs.orglett.0c01927 Le-Cheng Wang 1 , Shiying Du 1 , Zhengkai Chen 1 , Xiao-Feng Wu 1, 2
Affiliation
An FeCl3-mediated cascade coupling/decarbonylative annulation reaction for the efficient construction of 2-(trifluoromethyl)quinazolin-4(3H)-ones has been developed. This transformation employs readily available isatins and trifluoroacetimidoyl chlorides as the starting materials, providing a facile and practical route to diverse biologically relevant quinazolin-4(3H)-one derivatives. A plausible reaction pathway has been proposed based on the mechanistic observations.
中文翻译:
FeCl3介导的从靛红和三氟乙酰亚胺基氯的合成2-(三氟甲基)喹唑啉-4(3H)-酮。
已经开发出FeCl 3介导的级联偶合/脱羰环化反应,用于有效地构建2-(三氟甲基)喹唑啉-4(3 H)-one。该转化采用容易获得的靛红和三氟乙酰亚胺基氯作为起始原料,为各种生物学相关的喹唑啉-4(3H)-一衍生物提供了简便实用的途径。基于机理的观察已经提出了合理的反应途径。
更新日期:2020-07-17
中文翻译:
FeCl3介导的从靛红和三氟乙酰亚胺基氯的合成2-(三氟甲基)喹唑啉-4(3H)-酮。
已经开发出FeCl 3介导的级联偶合/脱羰环化反应,用于有效地构建2-(三氟甲基)喹唑啉-4(3 H)-one。该转化采用容易获得的靛红和三氟乙酰亚胺基氯作为起始原料,为各种生物学相关的喹唑啉-4(3H)-一衍生物提供了简便实用的途径。基于机理的观察已经提出了合理的反应途径。