External temperature variations inevitably affect the accuracy of surface plasmon resonance (SPR) biosensors. To that end, we propose an ultra-compact label-free dual-channel SPR fiber sensor (DSPRFS) that can simultaneously measure the glucose concentration and ambient temperature in real-time. The proposed sensor is based on a unique dual-channel structure fabricated by etching a side-hole fiber (SHF), and has significantly higher spatial sensitivity than traditional SPR biosensors. After coating with silver and zinc oxide films, one channel was filled with polydimethylsiloxane (PDMS) to sense the ambient temperature, and the other channel was immobilized with glucose oxidase (GOx) enzyme for glucose sensing. The proposed sensor is analyzed theoretically, fabricated and characterized. Glucose concentration sensitivity and temperature sensitivity of the manufactured sensor sample were found to be as high as 6.156 nm/mMand -1.604 nm/°C with limits of detection (LOD) of 16.24 µM and 0.06 °C, respectively. The proposed sensor has an extremely compact structure, enables temperature compensation, and is suitable for in-situ monitoring and high-precision sensing of glucose and other biological analytes.

中文翻译：

---

原位双通道表面等离子体共振纤维传感器，用于温度补偿的葡萄糖浓度检测。

外部温度变化不可避免地会影响表面等离子体共振（SPR）生物传感器的精度。为此，我们提出了一种超紧凑的无标签双通道SPR光纤传感器（DSPRFS），该传感器可以实时同时测量葡萄糖浓度和环境温度。所提出的传感器基于通过蚀刻侧孔光纤（SHF）制成的独特双通道结构，并且比传统的SPR生物传感器具有更高的空间灵敏度。在涂上氧化银和氧化锌薄膜后，一个通道填充有聚二甲基硅氧烷（PDMS）以感测环境温度，另一通道固定有葡萄糖氧化酶（GOx）酶以进行葡萄糖感测。对提出的传感器进行了理论分析，制造和表征。nm / mM和-1.604 nm / °C，检出限（LOD）分别为16.24 µM和0.06 °C。所提出的传感器具有极其紧凑的结构，能够进行温度补偿，并且适用于葡萄糖和其他生物分析物的现场监测和高精度传感。