The rapid, complete, targeted and safe treatment for tumors remains a key issue in cancer therapy. A novel treatment of solid tumors by supramolecular photocatalyst Nano-SA-TCPP with the irradiation of 600–700 nm wavelength is established. Solid tumors (100 mm³) can be eliminated within 10 min. The 50-day mouse survival rate was increased from 0% to 100% after the photocatalytic therapy. The breakthrough was owing to the cell membrane rupture and the cytoplasmic loss caused by photogenerated holes inside cancer cells. The porphyrin-based photocatalysts can be internalized in a targeted manner by cancer cells due to the size selection effect, without entering the normal cells. The therapy has no toxicity or side effects for normal cells and organisms. Moreover, the photocatalytic therapy is effective for a variety of cancer cell lines. Because of its high efficiency, safety and universality, the photocatalytic therapy provides us with a new lancet to conquer the tumor.

中文翻译：

---

超分子卟啉光催化剂光生空穴诱导快速消除实体瘤


肿瘤的快速、彻底、靶向和安全治疗仍然是癌症治疗的关键问题。建立了一种利用超分子光催化剂 Nano-SA-TCPP 在 600-700 nm 波长照射下治疗实体瘤的新方法。实体瘤（100mm ³ ）可在10分钟内消除。光催化治疗后，小鼠50天存活率从0%提高到100%。这一突破是由于癌细胞内光生孔引起的细胞膜破裂和细胞质损失。由于尺寸选择效应，卟啉基光催化剂可以被癌细胞靶向内化，而不进入正常细胞。该疗法对正常细胞和生物体没有毒性或副作用。此外，光催化疗法对多种癌细胞系有效。光催化疗法因其高效、安全、普适性等特点，为我们攻克肿瘤提供了新的刺血针。