Receptor Organization Determines the Limits of Single-Cell Source Location Detection.,Physical Review Letters

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Receptor Organization Determines the Limits of Single-Cell Source Location Detection.
Physical Review Letters ( IF 8.1 ) Pub Date : 2020-07-02 , DOI: 10.1103/physrevlett.125.018102
Sean D Lawley ₁ , Alan E Lindsay ₂ , Christopher E Miles ₃

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Many types of cells require the ability to pinpoint the location of an external stimulus from the arrival of diffusing signaling molecules at cell-surface receptors. How does the organization (number and spatial configuration) of these receptors shape the limit of a cell’s ability to infer the source location? In the idealized scenario of a spherical cell, we apply asymptotic analysis to compute splitting probabilities between individual receptors and formulate an information-theoretic framework to quantify the role of receptor organization. Clustered configurations of receptors provide an advantage in detecting sources aligned with the clusters, suggesting a possible multiscale mechanism for single-cell source inference.

中文翻译：

受体组织决定了单细胞源位置检测的极限。

许多类型的细胞都需要具有从扩散信号分子到达细胞表面受体处来确定外部刺激位置的能力。这些受体的组织（数量和空间构型）如何塑造细胞推断来源位置的能力极限？在球形细胞的理想情况下，我们应用渐近分析来计算各个受体之间的分裂概率，并建立一个信息理论框架来量化受体组织的作用。受体的簇状构型在检测与簇对齐的源中提供了优势，这暗示了单细胞源推断的可能的多尺度机制。

更新日期：2020-07-02

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