In COVID-19, lung manifestations present as a slowly evolving pneumonia with insidious early onset interstitial pulmonary edema that undergoes acute exacerbation in the late stages and microvascular thrombosis. Currently, these manifestations are considered to be only consequences of pulmonary SARS-CoV-2 virus infection. We are proposing a new hypothesis that neurogenic insult may also play a major role in the pathogenesis of these manifestations. SARS-CoV-2 mediated inflammation of the nucleus tractus solitarius (NTS) may play a role in the acute exacerbation of pulmonary edema and microvascular clotting in COVID-19 patients.

中文翻译：

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COVID19-A 神经假说中的肺水肿。

在 COVID-19 中，肺部表现表现为缓慢发展的肺炎，伴有隐匿的早发性间质性肺水肿，晚期急性加重和微血管血栓形成。目前，这些表现被认为只是肺部 SARS-CoV-2 病毒感染的后果。我们提出了一个新的假设，即神经源性损伤也可能在这些表现的发病机制中发挥重要作用。SARS-CoV-2 介导的孤束核 (NTS) 炎症可能在 COVID-19 患者肺水肿和微血管凝血的急性加重中发挥作用。