Currently, due to uprising concerns about wound infections, healing agents have been regarded as one of the major solutions in the treatment of different skin lesions. The usage of temporary barriers can be an effective way to protect wounds or ulcers from dangerous agents and, using these carriers can not only improve the healing process but also they can minimize the scarring and the pain suffered by the human. To cope with this demand, researchers struggled to develop wound dressing agents that could mimic the structural and properties of native skin with the capability to inhibit bacterial growth. Hence, asymmetric membranes that can impair bacterial penetration and avoid exudate accumulation as well as wound dehydration have been introduced. In general, synthetic implants and tissue grafts are expensive, hard to handle (due to their fragile nature and poor mechanical properties) and their production process is very time consuming, while the asymmetric membranes are affordable and their production process is easier than previous epidermal substitutes. Motivated by this, here we will cover different topics, first, the comprehensive research developments of asymmetric membranes are reviewed and second, general properties and different preparation methods of asymmetric membranes are summarized. In the two last parts, the role of chitosan based-asymmetric membranes and electrospun asymmetric membranes in hastening the healing process are mentioned respectively. The aforementioned membranes are inexpensive and possess high antibacterial and satisfactory mechanical properties. It is concluded that, despite the promising current investigations, much effort is still required to be done in asymmetric membranes.

中文翻译：

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不对称膜：伤口愈合应用的潜在支架

目前，由于对伤口感染的担忧日益加剧，愈合剂已被视为治疗不同皮肤病变的主要解决方案之一。使用临时屏障可以是保护伤口或溃疡免受危险因素侵害的有效方法，使用这些载体不仅可以改善愈合过程，还可以最大限度地减少疤痕和人类遭受的疼痛。为了满足这一需求，研究人员努力开发能够模拟天然皮肤结构和特性并具有抑制细菌生长能力的伤口敷料剂。因此，已经引入了可以削弱细菌渗透并避免渗出液积聚以及伤口脱水的不对称膜。一般来说，合成植入物和组织移植物价格昂贵，难以处理（由于它们的脆弱性和较差的机械性能）并且它们的生产过程非常耗时，而非对称膜价格合理，并且它们的生产过程比以前的表皮替代品更容易。受此启发，在这里我们将涵盖不同的主题，首先，回顾了非对称膜的综合研究进展，其次，总结了非对称膜的一般性质和不同的制备方法。在最后两部分中，分别提到了基于壳聚糖的非对称膜和电纺非对称膜在加速愈合过程中的作用。上述膜价格低廉且具有高抗菌性和令人满意的机械性能。结论是，尽管目前的调查很有希望，