Background: Depression and osteoporosis are severe public health problems. There are conflicting findings regarding the influence of depression on bone metabolism. The aim of the presented study was to compare bone turnover markers and vitamin D levels between patients treated for depression and healthy controls. Patients and Methods: We determined a concentration of osteocalcin, carboxy-terminal telopeptide of type I collagen (β-CTX), 25-hydroxyvitamin D (25OHD) and 1,25(OH)₂D₃ in 99 patients, aged 46.9 ± 11 years, treated for depression, as well as in 45 healthy subjects. Depressive status was determined with the Hamilton Depression Scale (HDRS). Results: In patients treated for depression, we demonstrated significantly lower osteocalcin concentrations (p < 0.03) and higher concentration of β-CTX (result on the border of significance; p = 0.08). Those relationship were stronger in women. The level of 25OHD and 1,25(OH)₂D₃ did not differ significantly between the examined groups. We observed a negative correlation between the 25OHD and HDRS score after treatment in all patients treated for depression and in subgroups of women and subjects with recurrent depression. Conclusions: Our results indicate that depression is related to disturbances in bone metabolism, especially in women and patients with recurrent depression, suggesting its role in context of osteoporosis development.

中文翻译：

---

治疗抑郁症的患者的骨代谢。

背景：抑郁症和骨质疏松症是严重的公共卫生问题。关于抑郁症对骨代谢的影响存在矛盾的发现。本研究的目的是比较接受抑郁症治疗的患者和健康对照者的骨转换指标和维生素D水平。患者和方法：我们确定了99名46.9±11岁的患者中骨钙素，I型胶原的羧基末端端肽（β-CTX），25-羟基维生素D（25OHD）和1,25（OH）₂ D ₃的浓度。年，治疗抑郁症以及45位健康受试者。抑郁状态由汉密尔顿抑郁量表（HDRS）确定。结果：在接受抑郁症治疗的患者中，我们证明了骨钙素浓度明显降低（p<0.03）和更高浓度的β-CTX（在显着性边界上得出；p = 0.08）。这些关系在女性中更为牢固。在两组之间，25OHD和1,25（OH）₂ D ₃的含量没有显着差异。我们观察到在所有接受抑郁治疗的患者以及女性亚组和复发性抑郁患者中，治疗后25OHD与HDRS得分之间呈负相关。结论：我们的结果表明抑郁症与骨代谢紊乱有关，尤其是在女性和复发性抑郁症患者中，提示其在骨质疏松症发展中的作用。