Small peptides are involved in countless biological processes. Hence selective binding motifs for peptides can be powerful tools for labeling or inhibition. Finding those binding motifs, especially in water which competes for intermolecular H-bonds, poses an enormous challenge. A dynamic combinatorial library can be a powerful method to overcome this issue. We previously reported artificial receptors emerging form a dynamic combinatorial library of peptide building blocks. In this study we aimed to broaden this scope towards recognition of small peptides. Employing CXC peptide building blocks, we found that cyclic dimers of oxidized CFC bind to the aromatic peptides FF and YY (K ≈ 229–702 M⁻¹), while AA binds significantly weaker (K ≈ 65–71 M⁻¹).

中文翻译：

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用于仿生识别水中二肽的动态组合库。

小肽参与了无数的生物过程。因此，肽的选择性结合基序可以成为标记或抑制的有力工具。寻找那些结合基序，尤其是在竞争分子间氢键的水中，提出了巨大的挑战。动态组合库可以是解决此问题的强大方法。我们之前报道过人工受体形成了一个动态的肽构建基组合库。在这项研究中，我们旨在将这一范围扩大到识别小肽。采用CXC肽积木，我们发现氧化的该环状二聚体CFC结合到芳族肽FF和YY（ķ ≈229-702中号^-1），而AA结合显著较弱（ķ ≈65-71中号^-1）。