Long Term Exposure to a Grape Seed Proanthocyanidin Extract Enhances L-Cell Differentiation in Intestinal Organoids.,Molecular Nutrition & Food Research

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Long Term Exposure to a Grape Seed Proanthocyanidin Extract Enhances L-Cell Differentiation in Intestinal Organoids.
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2020-07-08 , DOI: 10.1002/mnfr.202000303
Àngela Casanova-Martí ₁ , Noemi González-Abuín ₂ , Joan Serrano ₁ , Maria Teresa Blay ₁ , Ximena Terra ₁ , Gary Frost ₂ , Montserrat Pinent ₁ , Anna Ardévol ₁

Affiliation

A grape‐seed proanthocyanidin extract (GSPE) interacts at the intestinal level, enhancing glucagon‐like peptide‐1 (GLP‐1) and peptide YY (PYY) release, which modulate appetite and glucose homeostasis. Thus, enhancing L‐cell numbers could be a strategy to promote hormone production, providing a potential strategy for obesity and type‐2 diabetes mellitus (T2DM) treatment.

中文翻译：

长期暴露于葡萄籽原花青素提取物可增强肠道类器官中的 L 细胞分化。

葡萄籽原花青素提取物 (GSPE) 在肠道水平相互作用，增强胰高血糖素样肽 1 (GLP-1) 和肽 YY (PYY) 的释放，从而调节食欲和葡萄糖稳态。因此，增加 L 细胞数量可能是促进激素产生的一种策略，为肥胖和 2 型糖尿病 (T2DM) 治疗提供潜在策略。

更新日期：2020-07-08

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