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pH-Controlled Hierarchical Assembly/Disassembly of Multicompartment Micelles in Water.
Macromolecular Rapid Communications ( IF 4.2 ) Pub Date : 2020-07-01 , DOI: 10.1002/marc.202000301 Tai-Lam Nghiem 1 , Ramzi Chakroun 1 , Nicole Janoszka 1 , Chen Chen 1 , Kai Klein 2 , Chin Ken Wong 1 , André H Gröschel 1
Macromolecular Rapid Communications ( IF 4.2 ) Pub Date : 2020-07-01 , DOI: 10.1002/marc.202000301 Tai-Lam Nghiem 1 , Ramzi Chakroun 1 , Nicole Janoszka 1 , Chen Chen 1 , Kai Klein 2 , Chin Ken Wong 1 , André H Gröschel 1
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Multicompartment micelles (MCMs) have become attractive drug delivery systems as they allow the separate storage of two or more incompatible cargos in their core compartments (e.g., drugs and dyes for imaging). A recent hierarchical self‐assembly process for hydrophobic terpolymers in organic solvents showed the ability to form very homogeneous MCM populations, yet the transfer of this process into water requires a better understanding of the formation mechanism and influence of chain mobility during assembly. Here, the synthesis of a linear poly(oligo(ethylene glycol) methacrylate)‐block‐poly(benzyl acrylate)‐block‐poly(4‐vinylpyridine) (POEGMA‐b‐PBzA‐b‐P4VP) triblock terpolymer by reversible addition‐fragmentation chain transfer (RAFT) polymerization is reported as well as its step‐wise assembly into MCMs in water with POEGMA corona, PBzA patches, and P4VP core. Reversible assembly/disassembly of the MCMs is investigated through protonation/deprotonation of the P4VP core. Interestingly, the low glass transition temperature (Tg) of the hydrophobic PBzA middle block causes MCMs to directly disassemble into molecularly dissolved chains instead of patchy micelles due to mechanical stress from electrosteric repulsion of the protonated P4VP corona chains. In addition, pH resistant MCMs are created by core‐crosslinking and fluorescent properties are added by covalent anchoring of fluorescent dyes via straightforward click chemistry.
中文翻译：
pH控制的多隔室胶束在水中的分层组装/拆卸。
多隔室胶束（MCM）已成为有吸引力的药物输送系统，因为它们允许在其核心隔室中分别存储两种或更多种不相容的货物（例如，用于成像的药物和染料）。最近的有机溶剂中疏水性三元共聚物的分层自组装方法显示出能够形成非常均质的MCM种群的能力，但是该过程向水中的转移需要对组装过程中形成机理和链迁移率的影响有更好的了解。在这里，合成了线性聚（低聚（甲基丙烯酸乙二醇酯）-嵌段-聚（丙烯酸苄酯）-嵌段-聚（4-乙烯基吡啶）（POEGMA- b- PBzA- b报道了通过可逆加成-断裂链转移（RAFT）聚合反应制备的P4VP）三嵌段三元共聚物，以及将其逐步组装到带有POEGMA电晕，PBzA贴片和P4VP核的水中MCM中。通过P4VP核的质子化/去质子化研究了MCM的可逆组装/拆卸。有趣的是，由于质子化的P4VP电晕链的静电排斥产生的机械应力，疏水性PBzA中间嵌段的低玻璃化转变温度（T g）导致MCM直接分解成分子溶解的链，而不是斑块状的胶束。此外，通过核心交联产生了耐pH值的MCM，并通过直接点击化学将荧光染料共价锚定，从而增加了荧光特性。
更新日期：2020-07-01
中文翻译：
pH控制的多隔室胶束在水中的分层组装/拆卸。
多隔室胶束（MCM）已成为有吸引力的药物输送系统，因为它们允许在其核心隔室中分别存储两种或更多种不相容的货物（例如，用于成像的药物和染料）。最近的有机溶剂中疏水性三元共聚物的分层自组装方法显示出能够形成非常均质的MCM种群的能力，但是该过程向水中的转移需要对组装过程中形成机理和链迁移率的影响有更好的了解。在这里，合成了线性聚（低聚（甲基丙烯酸乙二醇酯）-嵌段-聚（丙烯酸苄酯）-嵌段-聚（4-乙烯基吡啶）（POEGMA- b- PBzA- b报道了通过可逆加成-断裂链转移（RAFT）聚合反应制备的P4VP）三嵌段三元共聚物，以及将其逐步组装到带有POEGMA电晕，PBzA贴片和P4VP核的水中MCM中。通过P4VP核的质子化/去质子化研究了MCM的可逆组装/拆卸。有趣的是，由于质子化的P4VP电晕链的静电排斥产生的机械应力，疏水性PBzA中间嵌段的低玻璃化转变温度（T g）导致MCM直接分解成分子溶解的链，而不是斑块状的胶束。此外，通过核心交联产生了耐pH值的MCM，并通过直接点击化学将荧光染料共价锚定，从而增加了荧光特性。
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