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Self-Assembling Glycopeptide Conjugate as a Versatile Platform for Mimicking Complex Polysaccharides.
Advanced Science ( IF 14.3 ) Pub Date : 2020-07-02 , DOI: 10.1002/advs.202001264
Hanxuan Wang 1 , Zhichao Liu 1 , Chuanjing An 1 , Haoting Li 1 , Fanlei Hu 2 , Suwei Dong 1
Affiliation  

Polysaccharides are a class of carbohydrates that play pivotal roles in living systems such as being chemical messengers in many vital biological pathways. However, the complexity and heterogeneity of these natural structures have posed daunting challenges on their production, characterization, evaluation, and applications. While there have been various types of synthetic skeletons that could mimic some biological aspects of polysaccharides, a safer and more easily accessed system is still desired to avoid the unnatural components and difficulties in modifying the structures. In this work, conveniently accessible self‐assembling glycopeptide conjugates are developed, where the natural O‐glycosidic linkages and phosphoryl modifications assist the self‐assembly and concurrently reduce the risk of toxicity. The generated nanoparticles in aqueous solution offer a multivalent display of structurally controllable carbohydrates as mimics of polysaccharides, among which a mannosylated version exhibits immunostimulatory effects in both cellular assays and vaccination of mice. The obtained results demonstrate the potential of this glycopeptide conjugate‐derived platform in exploiting the intriguing properties of carbohydrates in a more structurally maneuverable fashion.

中文翻译:


自组装糖肽缀合物作为模拟复杂多糖的多功能平台。



多糖是一类碳水化合物,在生命系统中发挥着关键作用,例如在许多重要的生物途径中充当化学信使。然而,这些自然结构的复杂性和异质性对其生产、表征、评估和应用提出了严峻的挑战。虽然已经有各种类型的合成骨架可以模拟多糖的某些生物学方面,但仍然需要一种更安全且更容易获得的系统,以避免非天然成分和修饰结构的困难。在这项工作中,开发了方便的自组装糖肽缀合物,其中天然的O-糖苷键和磷酰基修饰有助于自组装,同时降低毒性风险。水溶液中生成的纳米颗粒提供了结构可控碳水化合物的多价展示,作为多糖的模拟物,其中甘露糖化版本在细胞测定和小鼠疫苗接种中均表现出免疫刺激作用。获得的结果证明了这种糖肽缀合物衍生平台在以结构上更具可操作性的方式利用碳水化合物的有趣特性方面的潜力。
更新日期:2020-08-19
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