An efficient, simple and environmentally benign method for the construction of 1,3,4-thiadiazole skeletons via the tandem coupling and cyclization of thiohydrazides with DMF derivatives in the presence of KHSO₄ has been reported. This method reveals good reactivity and functional group tolerance, and a broad series of 1,3,4-thiadiazoles were obtained in moderate to good yields.

中文翻译：

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KHSO ₄促进了由硫酰肼和DMF衍生物串联合成1,3,4-噻二唑

据报道，在KHSO ₄存在下，通过硫代肼与DMF衍生物的串联偶联和环化反应，可以构建1,3,4-噻二唑骨架的一种高效，简单且环境友好的方法。该方法显示出良好的反应性和官能团耐受性，并以中等至良好的收率获得了一系列1,3,4-噻二唑。