Doxorubicin hydrochloride (DOX) is an effective anthracycline anticancer drug. However, the exceeded taken up could induce several side-effects such as cardiotoxicity, alopecia. Therefore, the level of DOX needs to be closely monitored to avoid the occurrence of its side-effects. Herein, we report a novel core CuInSe₂ - shell ZnS quantum dots (CuInSe₂@ZnS, QDs) and Ag nanoparticles (NPs) fluorescence sensor based on the surface plasmon resonance effect (SPR) of Ag NPs. The CuInSe₂@ZnS QDs were prepared by water phase reflux method with the 3-mercaptopropionic acid (MPA) as stabilizer and ligand. The fluorescence intensity of CuInSe₂@ZnS QDs/Ag NPs significantly reduced by DOX, which is mainly based on the electrostatic interaction between the DOX and fluorescence sensors. The inhibition of photoluminescence (ln F₀/F) was linearly relationship to the concentration of DOX in the range of 2–100 μM with the detection limit as low as 0.05 μM. The as-prepared sensor has a high selectivity and sensitivity to DOX. Furthermore, the new sensor has been successfully applied to the determination of DOX in human serum samples with satisfactory results. Our work provides a clue for developing a novel CuInSe₂@ZnS QDs/Ag NPs based fluorescence sensor for DOX detection.

盐酸阿霉素（DOX）是一种有效的蒽环类抗癌药。但是，超出的摄取量可能会引起一些副作用，例如心脏毒性，脱发。因此，需要严密监控DOX的水平，以避免其副作用的发生。在这里，我们基于Ag NPs的表面等离振子共振效应（SPR）报告了一种新型的核心CuInSe _2-壳ZnS量子点（CuInSe ₂ @ ZnS ，QDs）和Ag纳米颗粒（NPs）荧光传感器。以3-巯基丙酸（MPA）为稳定剂和配体，通过水相回流法制备了CuInSe ₂ @ZnS量子点。CuInSe ₂的荧光强度DOX显着减少了@ZnS QDs / Ag NPs，这主要是基于DOX和荧光传感器之间的静电相互作用。抑制光致发光（ln F ₀ / F）与DOX浓度在2–100μM范围内呈线性关系，检出限低至0.05μM。所准备的传感器对DOX具有很高的选择性和灵敏度。此外，该新型传感器已成功应用于人血清样品中DOX的测定，结果令人满意。我们的工作为开发新型的基于CuInSe ₂ @ZnS QDs / Ag NPs的用于DOX检测的荧光传感器提供了线索。