Background

The purpose of the present study is to investigate the correlation of plasma irisin level and hemodynamic parameters in patients with acute pulmonary embolism (APE) and to estimate clinical outcome prediction value of plasma irisin level.

Methods

We prospectively recruited 86 adult patients with APE in the present study. All recruited patients conduct measurement of plasma irisin levels using ELISA kits. Baseline clinical characteristics, hemodynamic parameters and prognostic conditions were evaluated according to different plasma irisin levels.

Results

According to median values of irisin levels, APE patients were divided into high irisin group (irisin≥6.9 μg/ml) and low irisin group (irisin<6.9 μg/ml). Plasma NT-proBNP (P = 0.044), mean pulmonary artery pressure (mPAP, P = 0.013), systolic pulmonary artery pressure (sPAP, P = 0.001), mean right ventricular pressure (mRVP, P = 0.021) and systolic right ventricular pressure (sPVP, P = 0.003) were higher in low irisin group compared with high irisin group. Hemodynamic parameters of mPAP, sPAP, mRVP and sRVP were negatively correlated with plasma irisin levels. Kaplan- Meier survival analysis showed that APE patients with lower plasma irisin levels had significantly higher clinical worsening event rate (P = 0.026) and could be the independent predictor of prognosis in multivariate analysis (P = 0.035).

Conclusion

Plasma irisin level was negatively correlated with hemodynamic parameters in patients with APE. Low irisin group patients had significantly higher clinical worsening event rate and could be the independent predictor of clinical outcome in multivariate analysis.

中文翻译：

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血浆虹膜素水平与血液动力学参数有关，并能预测急性肺栓塞患者的临床结局。

背景

本研究的目的是研究急性肺栓塞（APE）患者血浆鸢尾素水平与血液动力学参数之间的相关性，并评估血浆鸢尾素水平的临床结果预测价值。

方法

在本研究中，我们前瞻性招募了86名APE成人患者。所有招募的患者均使用ELISA试剂盒测量血浆虹膜素水平。根据血浆血浆虹膜素水平评估基线临床特征，血液动力学参数和预后情况。

结果

根据虹膜素水平的中位值，将APE患者分为高虹膜素组（irisin≥6.9μg/ ml）和低虹膜素组（irisin <6.9μg/ ml）。血浆NT-proBNP（P = 0.044），平均肺动脉压（mPAP，P = 0.013），收缩期肺动脉压（sPAP，P = 0.001），平均右心室压（mRVP，P = 0.021）和收缩期右心室压低虹膜素组（sPVP，P = 0.003）高于高虹膜素组。mPAP，sPAP，mRVP和sRVP的血流动力学参数与血浆虹膜素水平呈负相关。Kaplan-Meier生存分析表明，血浆鸢尾素水平较低的APE患者的临床恶化事件发生率显着较高（P = 0.026），并且可能是多因素分析中预后的独立预测因子（P = 0.035）。

结论

APE患者血浆虹膜素水平与血流动力学参数呈负相关。低虹膜素组患者的临床恶化事件发生率明显更高，并且可能是多因素分析中临床结局的独立预测因子。