Abstract Polymeric nerve guidance conduits (NGCs) with uniform tubular structure are widely used as scaffolds in nerve tissue engineering. However, massive collapse of NGCs has greatly impeded their further application. Therefore, the gradient degradable nerve guidance conduit (GD-NGC) with multilayer structure is designed and fabricated via electrospinning technique. The GD-NGC consists of five poly(lactic-co-glycolic acid) (PLGA) layers with different polylactic acid (PLA)/polyglycolic acid (PGA) ratios. Compared to common NGCs, the novel GD-NGC degrades moderately and stepwise from inner to outer layers and also exhibits equivalent or better characteristics, such as porosity, water absorption capacity, mechanical property and biocompatibility. Collectively, GD-NGC has a promising potential for applications in nerve tissue engineering.

中文翻译：

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静电纺丝制备多层结构梯度可降解神经引导导管

摘要 具有均匀管状结构的聚合物神经引导导管（NGC）在神经组织工程中被广泛用作支架。然而，NGCs的大规模崩溃极大地阻碍了它们的进一步应用。因此，通过静电纺丝技术设计和制造了具有多层结构的梯度可降解神经引导导管（GD-NGC）。GD-NGC 由五个聚乳酸-乙醇酸共聚物 (PLGA) 层组成，具有不同的聚乳酸 (PLA)/聚乙醇酸 (PGA) 比率。与普通NGCs相比，新型GD-NGCs从内到外层适度逐步降解，并表现出同等或更好的特性，如孔隙率、吸水能力、机械性能和生物相容性。总的来说，GD-NGC 在神经组织工程中具有广阔的应用潜力。