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Long non-coding RNA TINCR as potential biomarker and therapeutic target for cancer
Life Sciences ( IF 5.2 ) Pub Date : 2020-07-02 , DOI: 10.1016/j.lfs.2020.118035 Uttam Sharma 1 , Tushar Singh Barwal 1 , Akshay Malhotra 2 , Neha Pant 1 , Vivek 1 , Damayanti Dey 1 , Ashima Gautam 1 , Hardeep Singh Tuli 3 , Karen M Vasquez 4 , Aklank Jain 1
Life Sciences ( IF 5.2 ) Pub Date : 2020-07-02 , DOI: 10.1016/j.lfs.2020.118035 Uttam Sharma 1 , Tushar Singh Barwal 1 , Akshay Malhotra 2 , Neha Pant 1 , Vivek 1 , Damayanti Dey 1 , Ashima Gautam 1 , Hardeep Singh Tuli 3 , Karen M Vasquez 4 , Aklank Jain 1
Affiliation
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Despite the recent scientific advances made in cancer diagnostics and therapeutics, cancer still remains the second leading cause of death worldwide. Thus, there is a need to identify new potential biomarkers/molecular targets to improve the diagnosis and treatment of cancer patients. In this regard, long non-coding RNAs (lncRNAs), a type of non-coding RNA molecule, have been found to play important roles in diverse biological processes, including tumorigenesis, and may provide new biomarkers and/or molecular targets for the improved detection of treatment of cancer. For example, one lncRNA, tissue differentiation-inducing non-protein coding RNA () has been found to be significantly dysregulated in many cancers, and has an impact on tumor development and progression through targeting pivotal molecules in cancer-associated signaling pathways. Hence, based on recent discoveries, herein, we discuss the regulatory functions and the underlying mechanisms of how regulates signaling pathways attributed to cancer hallmarks associated with the pathogenesis of various human cancers. We also highlight studies assessing its potential clinical utility as a biomarker/target for early detection, cancer risk stratification, and personalized cancer therapies.
中文翻译：
长链非编码RNA TINCR作为癌症的潜在生物标志物和治疗靶点
尽管最近在癌症诊断和治疗方面取得了科学进展，但癌症仍然是全球第二大死亡原因。因此，需要识别新的潜在生物标志物/分子靶点来改善癌症患者的诊断和治疗。在这方面，长链非编码RNA（lncRNA）是一种非编码RNA分子，已被发现在包括肿瘤发生在内的多种生物过程中发挥重要作用，并可能为改善肿瘤发生提供新的生物标志物和/或分子靶点。检测癌症的治疗。例如，一种 lncRNA（组织分化诱导非蛋白编码 RNA）被发现在许多癌症中显着失调，并通过靶向癌症相关信号通路中的关键分子对肿瘤的发生和进展产生影响。因此，基于最近的发现，本文讨论了如何调节与各种人类癌症发病机制相关的癌症标志信号通路的调节功能和潜在机制。我们还重点评估其作为早期检测、癌症风险分层和个性化癌症治疗的生物标志物/靶标的潜在临床效用的研究。
更新日期：2020-07-02
中文翻译：
长链非编码RNA TINCR作为癌症的潜在生物标志物和治疗靶点
尽管最近在癌症诊断和治疗方面取得了科学进展，但癌症仍然是全球第二大死亡原因。因此，需要识别新的潜在生物标志物/分子靶点来改善癌症患者的诊断和治疗。在这方面，长链非编码RNA（lncRNA）是一种非编码RNA分子，已被发现在包括肿瘤发生在内的多种生物过程中发挥重要作用，并可能为改善肿瘤发生提供新的生物标志物和/或分子靶点。检测癌症的治疗。例如，一种 lncRNA（组织分化诱导非蛋白编码 RNA）被发现在许多癌症中显着失调，并通过靶向癌症相关信号通路中的关键分子对肿瘤的发生和进展产生影响。因此，基于最近的发现，本文讨论了如何调节与各种人类癌症发病机制相关的癌症标志信号通路的调节功能和潜在机制。我们还重点评估其作为早期检测、癌症风险分层和个性化癌症治疗的生物标志物/靶标的潜在临床效用的研究。
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