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α-Tricalcium phosphate/fluorapatite based composite cements: Synthesis, mechanical properties, and biocompatibility
Ceramics International ( IF 5.1 ) Pub Date : 2020-11-01 , DOI: 10.1016/j.ceramint.2020.06.301
A. Kazuz , Ž. Radovanović , Dj. Veljović , V. Kojić , V. Miletić , R. Petrović , Dj. Janaćković

Abstract Composite cements based on α-tricalcium phosphate (α-TCP) and nanostructured fluorapatite (FAp), α-TCP/FAp, appropriate for dental usage as root canal filling material, have been prepared with the improved mechanical properties and biocompatibility. The influence of FAp concentration on the composite cement properties was investigated. The processing conditions for FAp powders synthesis were optimized and the powder with optimal properties was chosen to obtain α-TCP/FAp composite types of cement. α-TCP powder was prepared by calcination of hydrothermally synthesized hydroxyapatite (HAp) at 1500 °C for 2 h. Morphology and phase composition of powders were investigated by X-ray diffraction (XRD), Fourier transformed infrared spectroscopy (FTIR), Field emission scanning electron microscopy (FESEM), and energy dispersive X-ray spectroscopy (EDS). Soaking of α-TCP/FAp specimens in simulated body fluid (SBF) affected the successful transformation of α-TCP into HAp, while the compressive test revealed the influence of this transformation and FAp content on the mechanical properties of the composites. Specimen containing 5% of FAp after 10 days in SBF showed the highest compressive strength. In vitro MTT and DET biocompatibility tests, performed in the culture of MRC-5 human fibroblast cells, revealed that α-TCP/FAp had no cytotoxic effect. These initial findings showed that α-TCP/FAp composite cements could yield favorable mechanical properties with no adverse effect on biocompatibility.

中文翻译:

α-磷酸三钙/氟磷灰石基复合水泥:合成、机械性能和生物相容性

摘要 基于α-磷酸三钙(α-TCP)和纳米结构氟磷灰石(FAp)的复合水门汀,α-TCP/FAp,适用于牙科作为根管充填材料,具有改善的力学性能和生物相容性。研究了FAp浓度对复合水泥性能的影响。对FAp粉体合成工艺条件进行优化,选择性能最优的粉体,获得α-TCP/FAp复合型水泥。α-TCP 粉末是通过将水热合成的羟基磷灰石 (HAp) 在 1500°C 下煅烧 2 小时来制备的。通过 X 射线衍射 (XRD)、傅里叶变换红外光谱 (FTIR)、场发射扫描电子显微镜 (FESEM)、和能量色散 X 射线光谱 (EDS)。将α-TCP/FAp 试样浸泡在模拟体液(SBF)中影响了α-TCP 成功转化为HAp,而压缩试验揭示了这种转化和FAp 含量对复合材料力学性能的影响。在 SBF 中放置 10 天后,含有 5% FAp 的试样显示出最高的抗压强度。在 MRC-5 人成纤维细胞培养物中进行的体外 MTT 和 DET 生物相容性测试表明,α-TCP/FAp 没有细胞毒性作用。这些初步发现表明,α-TCP/FAp 复合水泥可以产生良好的机械性能,而不会对生物相容性产生不利影响。而压缩试验揭示了这种转变和 Fap 含量对复合材料力学性能的影响。在 SBF 中放置 10 天后,含有 5% FAp 的试样显示出最高的抗压强度。在 MRC-5 人成纤维细胞培养物中进行的体外 MTT 和 DET 生物相容性测试表明,α-TCP/FAp 没有细胞毒性作用。这些初步发现表明,α-TCP/FAp 复合水泥可以产生良好的机械性能,而不会对生物相容性产生不利影响。而压缩试验揭示了这种转变和 Fap 含量对复合材料力学性能的影响。在 SBF 中放置 10 天后,含有 5% FAp 的试样显示出最高的抗压强度。在 MRC-5 人成纤维细胞培养物中进行的体外 MTT 和 DET 生物相容性测试表明,α-TCP/FAp 没有细胞毒性作用。这些初步发现表明,α-TCP/FAp 复合水泥可以产生良好的机械性能,而不会对生物相容性产生不利影响。显示α-TCP/FAp没有细胞毒性作用。这些初步发现表明,α-TCP/FAp 复合水泥可以产生良好的机械性能,而不会对生物相容性产生不利影响。显示α-TCP/FAp没有细胞毒性作用。这些初步发现表明,α-TCP/FAp 复合水泥可以产生良好的机械性能,而不会对生物相容性产生不利影响。
更新日期:2020-11-01
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