Exosomes are nanosized vesicles with a lipid membrane that are secreted by most cells and play a crucial role as intermediates of intercellular communication because they carry bioactive molecules. Exosomes are promising for drug delivery of chemicals, proteins, and nucleic acids owing to their inherent properties such as excellent biocompatibility, high tumor targetability, and prolonged circulation in vivo. In this review, we cover recent approaches and advances made in the field of exosome-mediated delivery of bioactive molecules for cancer therapy and factors that affect the clinical use of exosomes. This review can be used as a guideline for further study in expanding the utility of therapeutic exosomes.

外泌体是具有脂质膜的纳米大小的囊泡，大多数细胞会分泌这种膜，并且由于它们携带生物活性分子，因此作为细胞间通讯的中间体起着至关重要的作用。外来体因其固有的特性（例如出色的生物相容性，高肿瘤靶向性和体内延长循环）而有望用于化学药品，蛋白质和核酸的药物递送。在这篇综述中，我们涵盖了在外来体介导的用于癌症治疗的生物活性分子的递送和影响外来体临床使用的因素方面的最新方法和进展。本文可作为进一步研究扩大治疗性外泌体效用的指南。