Abstract.

Understanding the mechanisms responsible for the formation and growth of FtsZ polymers and their subsequent formation of the Z -ring is important for gaining insight into the cell division in prokaryotic cells. In this work, we present a minimal stochastic model that qualitatively reproduces in vitro observations of polymerization, formation of dynamic contractile ring that is stable for a long time and depolymerization shown by FtsZ polymer filaments. In this stochastic model, we explore different mechanisms for ring breaking and hydrolysis. In addition to hydrolysis, which is known to regulate the dynamics of other tubulin polymers like microtubules, we find that the presence of the ring allows for an additional mechanism for regulating the dynamics of FtsZ polymers. Ring breaking dynamics in the presence of hydrolysis naturally induce rescue and catastrophe events in this model irrespective of the mechanism of hydrolysis.

Graphical abstract

中文翻译：

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FtsZ细丝动力学和Z形环形成的随机模型。

摘要。

了解负责FtsZ聚合物的形成和生长以及它们随后形成Z环的机理，对于深入了解原核细胞中的细胞分裂非常重要。在这项工作中，我们提出了一种定性地在体外复制的最小随机模型FtsZ聚合物长丝显示聚合反应，形成稳定的动态收缩环以及长期解聚的结果。在这种随机模型中，我们探索了不同的环断裂和水解机理。除了已知可调节其他微管蛋白聚合物（如微管）动力学的水解反应外，我们发现环的存在还允许调节FtsZ聚合物动力学的其他机制。不管水解机理如何，在存在水解的情况下，环断裂动力学都会在该模型中自然引发救援和灾难事件。

图形概要