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A review on the synthesis and applications of molecules as anticonvulsant drug agent candidates
Medicinal Chemistry Research ( IF 2.6 ) Pub Date : 2020-07-02 , DOI: 10.1007/s00044-020-02595-4
Oguz Özbek , Meliha Burcu Gürdere

Epilepsy is one of the most common neurological disorders worldwide and it requires a long-term or life-long treatment. Current standard treatment includes the use of antiepileptic drugs. To date, many organic compounds have been synthesized by chemists as potential antiepileptic drugs and their anticonvulsant properties have been investigated. While evaluating the anticonvulsant activities of these newly synthesized molecules, known antiepileptic drugs are used as reference. Thus, many novel molecules with anticonvulsant properties have been added to the literature. It is clear that these new molecules will be effective in the treatment of epilepsy. In this review, we investigated the synthesis and properties of organic compounds with anticonvulsant properties.

中文翻译:

抗惊厥药物候选分子的合成与应用研究进展

癫痫病是全世界最常见的神经系统疾病之一,需要长期或终生治疗。当前的标准治疗包括使用抗癫痫药。迄今为止,化学家已经合成了许多有机化合物作为潜在的抗癫痫药,并且已经研究了它们的抗惊厥性质。在评估这些新合成分子的抗惊厥活性时,使用已知的抗癫痫药作为参考。因此,许多具有抗惊厥特性的新型分子已被添加到文献中。显然,这些新分子将有效治疗癫痫病。在这篇综述中,我们研究了具有抗惊厥性质的有机化合物的合成和性质。
更新日期:2020-07-02
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