Although numerous materials have been explored as bone scaffolds, many of them are limited by their low osteoconductivity and high biodegradability. Therefore, new materials are desired to induce bone cell proliferation and facilitate bone formation. Attapulgite (ATP) is a hydrated silicate that exists in nature as a fibrillar clay mineral and is well known for its large specific surface area, high viscosity, and high absorption capacity, and therefore has the potential to be a new type of bone repair material due to its unique physicochemical properties. In this study, composite scaffolds composed of collagen/polycaprolactone/attapulgite (CPA) or collagen/polycaprolactone (CP) were fabricated through a salt-leaching method. The morphology, composition, microstructure, physical, and mechanical characteristics of the CPA and CP scaffolds were assessed. Cells from the mouse multipotent mesenchymal precursor cell line (D1 cells) were cocultured with the scaffolds, and cell adhesion...

中文翻译：

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用于兔模型体内骨修复的胶原蛋白、聚己内酯和凹凸棒石复合支架。

尽管已经探索了许多材料作为骨支架，但其中许多材料受到其低骨传导性和高生物降解性的限制。因此，需要新材料来诱导骨细胞增殖并促进骨形成。凹凸棒石（ATP）是一种水合硅酸盐，以纤维状粘土矿物形式存在于自然界中，以其大比表面积、高粘度和高吸收能力而著称，因此具有成为新型骨修复材料的潜力由于其独特的物理化学性质。在这项研究中，通过盐浸法制备了由胶原蛋白/聚己内酯/凹凸棒石（CPA）或胶原蛋白/聚己内酯（CP）组成的复合支架。形态、成分、微观结构、物理、并评估了 CPA 和 CP 支架的机械特性。来自小鼠多能间充质前体细胞系（D1细胞）的细胞与支架共培养，细胞粘附...