Periprosthetic joint infection (PJI) is one of the most pivotal issues accounting for clinical failure of titanium (Ti)-based implants. Therefore, it is of great significance to develop an antibacterial coating with high biocompatibility on the Ti implant surface. In this article, a novel zinc-doped strontium phosphate coating, denoted as Sr-Zn-PCC, was deposited on Ti substrates by phosphate chemical conversion (PCC) method. The texture characterizations indicated that continuous coatings containing SrHPO 4 , Sr 3 (PO 4 ) 2 and SrZn 2 (PO 4 ) 2 phases were formed on the Ti surface. It is found that the doping of Zn could tune the surface microstructure, roughness, wettability and corrosion resistance of the coatings. The Sr-Zn-PCC coating showed the same bacterial adhesion property at short time (2 h), but tended to hinder biofilm formation on coatings after incubation for up to 24 h. Up to 80% of Staphylococcu...

中文翻译：

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含锌磷酸锶锶涂层对钛的抗菌活性和细胞相容性

假体周围关节感染（PJI）是导致钛（Ti）植入物临床失败的最关键问题之一。因此，开发在钛植入物表面具有高生物相容性的抗菌涂层具有重要意义。在本文中，通过磷酸盐化学转化（PCC）方法在Ti基片上沉积了一种新型的掺锌磷酸锶锶涂层，称为Sr-Zn-PCC。织构特征表明在Ti表面上形成了包含SrHPO 4，Sr 3（PO 4）2和SrZn 2（PO 4）2相的连续涂层。发现锌的掺杂可以调节涂层的表面微观结构，粗糙度，润湿性和耐蚀性。Sr-Zn-PCC涂层在短时间内（2 h）表现出相同的细菌粘附特性，但在孵育长达24小时后，往往会阻碍涂层上生物膜的形成。高达80％的葡萄球菌...