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Symptoms of titanium and nickel allergic sensitization in orthodontic treatment.
Progress in Orthodontics ( IF 3.5 ) Pub Date : 2020-07-01 , DOI: 10.1186/s40510-020-00318-4
Martina Zigante 1 , Marijana Rincic Mlinaric 2 , Marija Kastelan 3 , Vjera Perkovic 1 , Magda Trinajstic Zrinski 1 , Stjepan Spalj 1, 4
Affiliation  

The study aimed to evaluate to which extent self-reported symptomatology, age, and sex are predictors of titanium and nickel allergic sensitization in patients in treatment with fixed orthodontic appliances. The study analyzed 228 subjects aged 11–45 years (median 18, interquartile range 16–22); 68% of them were females, and 52% were adolescents. The allergic sensitization testing included epicutaneous patch test to titanium, titanium dioxide, titanium oxalate, titanium nitride, and nickel sulfate. The questionnaire on symptoms potentially linked to titanium and nickel sensitization was used. Prevalence of the allergic sensitization to titanium in patients undergoing orthodontic treatment was 4% (2% only to titanium without nickel) while to nickel 14% (12% nickel without titanium). Hypersensitivity to both metals at the same time was present in 2% of subjects. Sensitization to nickel was more common in females than in males (17 vs. 8%) and much more common in adults than in adolescents with small effect size (20 vs. 8%; p = 0.013). Sensitization to titanium was more common in females than in males (6 vs. 1%) with no difference in age. Multiple logistic regression analysis revealed that adult age increases the odds for being sensitized to nickel for 2.4 × (95% CI 1.1–5.6; p = 0.044) while watery eyes for 3.7 × (95% CI 1.2–11.1; p = 0.022). None of the symptoms were significant predictors of titanium sensitization. Allergic sensitization to titanium and nickel are not very frequent in orthodontic patients, and self-reported symptomatology is a weak predictor of those sensitizations.

中文翻译:

正畸治疗中钛和镍过敏性过敏的症状。

这项研究旨在评估自我报告的症状,年龄和性别在使用正畸矫治器治疗的患者中钛和镍过敏敏化的预测因素。该研究分析了228名年龄在11-45岁(中位数18,四分位间距16-22)的受试者。其中68%是女性,而52%是青少年。过敏性致敏测试包括对钛,二氧化钛,草酸钛,氮化钛和硫酸镍的表皮贴剂测试。使用关于可能与钛和镍敏化有关的症状的问卷。在接受正畸治疗的患者中,对钛过敏的患病率为4%(仅对不含镍的钛为2%),对镍为14%(不含钛的镍为12%)。2%的受试者同时对两种金属过敏。女性对镍的敏感性比男性高(17比8%),成年人比对青少年的镍敏感性高(20比8%; p = 0.013)。女性对钛的增感比男性更普遍(6比1%),年龄没有差异。多元逻辑回归分析显示,成年年龄增加对镍敏感的几率是2.4×(95%CI 1.1–5.6; p = 0.044),而水汪汪的眼睛是3.7×(95%CI 1.2-11.1; p = 0.022)。这些症状均不是钛致敏的重要预测指标。在正畸患者中,对钛和镍的过敏性过敏反应不是很常见,自我报告的症状学对这些过敏性反应的预测较弱。女性对镍的敏感性比男性高(17比8%),成年人比对青少年的镍敏感性高(20比8%; p = 0.013)。女性对钛的增感比男性更普遍(6比1%),年龄没有差异。多元逻辑回归分析显示,成年年龄增加对镍敏感的几率是2.4×(95%CI 1.1–5.6; p = 0.044),而水汪汪的眼睛是3.7×(95%CI 1.2-11.1; p = 0.022)。这些症状均不是钛致敏的重要预测指标。在正畸患者中,对钛和镍的过敏性过敏反应不是很常见,自我报告的症状学对这些过敏性反应的预测很弱。女性对镍的敏感性比男性高(17比8%),成年人比对青少年的镍敏感性高(20比8%; p = 0.013)。女性对钛的增感比男性更普遍(6比1%),年龄没有差异。多元逻辑回归分析显示,成年年龄增加对镍敏感的几率是2.4×(95%CI 1.1–5.6; p = 0.044),而水汪汪的眼睛是3.7×(95%CI 1.2-11.1; p = 0.022)。这些症状均不是钛致敏的重要预测指标。正畸患者对钛和镍的过敏性过敏反应不是很常见,自我报告的症状学对这些过敏性反应的预测很弱。(8%)和比效果较小的青少年更为常见(20 vs. 8%; p = 0.013)。女性对钛的过敏比男性更普遍(6比1%),年龄没有差异。多元逻辑回归分析显示,成年年龄增加对镍敏感的几率是2.4×(95%CI 1.1–5.6; p = 0.044),而水汪汪的眼睛是3.7×(95%CI 1.2-11.1; p = 0.022)。这些症状均不是钛致敏的重要预测指标。在正畸患者中,对钛和镍的过敏性过敏反应不是很常见,自我报告的症状学对这些过敏性反应的预测很弱。(8%)和比效果较小的青少年更为常见(20 vs. 8%; p = 0.013)。女性对钛的过敏比男性更普遍(6比1%),年龄没有差异。多元逻辑回归分析显示,成年年龄增加对镍敏感的几率是2.4×(95%CI 1.1–5.6; p = 0.044),而水汪汪的眼睛是3.7×(95%CI 1.2-11.1; p = 0.022)。这些症状均不是钛致敏的重要预测指标。在正畸患者中,对钛和镍的过敏性过敏反应不是很常见,自我报告的症状学对这些过敏性反应的预测很弱。多元逻辑回归分析显示,成年年龄增加对镍敏感的几率是2.4×(95%CI 1.1–5.6; p = 0.044),而水汪汪的眼睛是3.7×(95%CI 1.2-11.1; p = 0.022)。这些症状均不是钛致敏的重要预测指标。正畸患者对钛和镍的过敏性过敏反应不是很常见,自我报告的症状学对这些过敏性反应的预测很弱。多元逻辑回归分析显示,成年年龄增加对镍敏感的几率是2.4×(95%CI 1.1–5.6; p = 0.044),而水汪汪的眼睛是3.7×(95%CI 1.2-11.1; p = 0.022)。这些症状均不是钛致敏的重要预测指标。在正畸患者中,对钛和镍的过敏性过敏反应不是很常见,自我报告的症状学对这些过敏性反应的预测很弱。
更新日期:2020-07-01
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