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A short peptide that preferentially binds c-MYC G-quadruplex DNA.
Chemical Communications ( IF 4.3 ) Pub Date : 2020-07-01 , DOI: 10.1039/d0cc02954h Aisling Minard 1 , Danielle Morgan , Federica Raguseo , Anna Di Porzio , Denise Liano , Andrew G Jamieson , Marco Di Antonio
Chemical Communications ( IF 4.3 ) Pub Date : 2020-07-01 , DOI: 10.1039/d0cc02954h Aisling Minard 1 , Danielle Morgan , Federica Raguseo , Anna Di Porzio , Denise Liano , Andrew G Jamieson , Marco Di Antonio
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G-quadruplexes (G4s) are non-canonical DNA secondary structures. The identification of selective tools to probe individual G4s over the ∼700 000 found in the human genome is key to unravel the biological significance of specific G4s. We took inspiration from a crystal structure of the bovine DHX36 helicase bound to the G4 formed in the promoter region of the oncogene c-MYC to identify a short peptide that preferentially binds MYC G4 with nM affinity over a small panel of parallel and non-parallel G4s tested.
中文翻译：
一种短肽，可优先结合c-MYC G-四链体DNA。
G-四链体（G4s）是非规范的DNA二级结构。鉴定探测人类基因组中约70万个以上G4s的选择性工具是揭示特定G4s生物学意义的关键。我们从与致癌基因c-MYC启动子区域中形成的G4结合的牛DHX36解旋酶的晶体结构中汲取了灵感，以鉴定出短肽，该短肽优先以一小部分平行和非平行的nM亲和力结合MYC G4。 G4s经过测试。
更新日期：2020-08-06
中文翻译：
一种短肽，可优先结合c-MYC G-四链体DNA。
G-四链体（G4s）是非规范的DNA二级结构。鉴定探测人类基因组中约70万个以上G4s的选择性工具是揭示特定G4s生物学意义的关键。我们从与致癌基因c-MYC启动子区域中形成的G4结合的牛DHX36解旋酶的晶体结构中汲取了灵感，以鉴定出短肽，该短肽优先以一小部分平行和非平行的nM亲和力结合MYC G4。 G4s经过测试。
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