Biological and mechanical properties of biodegradable polymeric composite materials are strongly influenced by the choice of appropriate reinforcement in the polymer matrix. Non-compatibility of material in the vascular system could obstruct the way of the biological fluids. The concept of development of polymeric composite material for vascular implants is to provide enough support to the vessel and to restore the vessel in the natural state after degradation. In this research, the polycaprolactone composite materials (carbonyl iron powder/polycaprolactone) were developed by reinforcement of the 0%–2% of carbonyl iron powder using the solvent cast three-dimensional printing technique. The physicochemical properties of developed composites were characterized in conjunction with mechanical and biological properties. The mechanical characterizations were assessed by uniaxial tensile testing as well as flexibility testing. The results of mechanical testing assured that carbonyl iron powder/polycaprolactone composites have shown desirable properties for vascular implants. Besides the mechanical characterization, in vitro biological investigations of carbonyl iron powder/polycaprolactone were done for analyzing blood compatibility and cytocompatibility. The results revealed that the materials developed were biocompatible, less hemolytic, and having non-thrombogenic properties indicating the promising applications in the field of cardiovascular applications.

生物可降解聚合物复合材料的生物学和机械性能受聚合物基体中适当增强材料的选择的强烈影响。血管系统中材料的不相容性可能会阻碍生物体液的通过。开发血管植入用高分子复合材料的理念是为血管提供足够的支撑，并使血管在降解后恢复到自然状态。本研究采用溶剂浇注三维打印技术对0%~2%的羰基铁粉进行增强，开发出聚己内酯复合材料（羰基铁粉/聚己内酯）。开发的复合材料的物理化学特性与机械和生物特性相结合。通过单轴拉伸测试以及柔韧性测试评估机械特性。机械测试结果确保羰基铁粉/聚己内酯复合材料已显示出理想的血管植入物特性。除了机械特性外，还对羰基铁粉/聚己内酯进行了体外生物学研究，以分析血液相容性和细胞相容性。结果表明，所开发的材料具有生物相容性、溶血性低和非血栓形成特性，表明在心血管应用领域具有广阔的应用前景。机械测试结果确保羰基铁粉/聚己内酯复合材料已显示出理想的血管植入物特性。除了机械特性外，还对羰基铁粉/聚己内酯进行了体外生物学研究，以分析血液相容性和细胞相容性。结果表明，所开发的材料具有生物相容性、溶血性低和非血栓形成特性，表明在心血管应用领域具有广阔的应用前景。机械测试结果确保羰基铁粉/聚己内酯复合材料已显示出理想的血管植入物特性。除了机械特性外，还对羰基铁粉/聚己内酯进行了体外生物学研究，以分析血液相容性和细胞相容性。结果表明，所开发的材料具有生物相容性、溶血性低和非血栓形成特性，表明在心血管应用领域具有广阔的应用前景。