We sought to investigate the effect of extracts from Rosa gallica petals (RPE) on skin whitening and anti-wrinkle activity. Tyrosinase activity was attenuated by RPE treatment, concomitant with the reduction of melanin accumulation in human B16F10 melanoma. Treatment of the facial skin of volunteers in a clinical trial with an RPE-containing formulation enhanced skin brightness (L* value) significantly. The underlying mechanism responsible was determined to be associated with mitogen-activated protein kinase (MAPK) activation. In addition, RPE exhibited anti-wrinkle formation activity of human dermal fibroblasts by suppressing matrix metalloproteinase (MMP)-1 level. In vivo study, RPE also inhibited solar ultraviolet-stimulated MMP-1 level by c-Jun regulation. Overall, our findings indicate that RPE evokes skin whitening and anti-wrinkle formation activity by regulating intracellular signaling, supporting its utility as an ingredient for skin whitening and anti-wrinkle cosmetic products.

中文翻译：

---

玫瑰花瓣提取物（Rosa gallica）具有美白皮肤和抗皮肤皱纹的作用。

我们试图研究玫瑰蔷薇花瓣（RPE）提取物对皮肤增白和抗皱活性的作用。酪氨酸酶活性通过RPE处理而减弱，同时减少了人B16F10黑色素瘤中黑色素的积累。在临床试验中，使用含有RPE的配方治疗志愿者的面部皮肤可以显着提高皮肤的亮度（L *值）。确定负责的潜在机制与有丝分裂原激活的蛋白激酶（MAPK）激活有关。此外，RPE通过抑制基质金属蛋白酶（MMP）-1水平，显示出人类皮肤成纤维细胞的抗皱形成活性。体内研究表明，RPE还可以通过c-Jun调节抑制太阳紫外线刺激的MMP-1水平。总体而言，我们的发现表明RPE通过调节细胞内信号传导来唤起皮肤增白和抗皱形成活性，支持其用作皮肤增白和抗皱化妆品的成分。