Background. Stress cardiomyopathy (SCM) is a transient reversible left ventricular dysfunction that more often occurs in women. Symptoms of SCM patients are similar to those of acute coronary syndrome (ACS), but little is known about biomarkers. The goals of this study were to identify the potentially crucial genes and pathways associated with SCM. Methods. We analyzed microarray datasets GSE95368 derived from the Gene Expression Omnibus (GEO) database. Firstly, identify the differentially expressed genes (DEGs) between SCM patients in normal patients. Then, the DEGs were used for Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis. Finally, the protein-protein interaction (PPI) network was constructed and Cytoscape was used to find the key genes. Results. In total, 25 DEGs were identified, including 10 upregulated genes and 15 downregulated genes. These DEGs were mainly enriched in ECM-receptor interaction, dilated cardiomyopathy (DCM), human papillomavirus infection, and focal adhesion, whereas in GO function classification, they were mainly enriched in the extracellular region, positive regulation of the multicellular organismal process, establishment of localization, and intracellular vesicle. Conclusion. Seven hub genes contained APOE, MFGE8, ALB, APOB, SAA1, A2M, and C3 identified as hub genes of SCM, which might be used as diagnostic biomarkers or molecular targets for the treatment of SCM.

中文翻译：

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MFGE8、ALB、APOB、APOE、SAA1、A2M 和 C3 作为应激性心肌病的新型生物标志物。


背景。应激性心肌病（SCM）是一种短暂的可逆性左心室功能障碍，更常见于女性。 SCM 患者的症状与急性冠脉综合征 (ACS) 相似，但人们对生物标志物知之甚少。本研究的目标是确定与 SCM 相关的潜在关键基因和途径。方法。我们分析了源自基因表达综合 (GEO) 数据库的微阵列数据集 GSE95368。首先，鉴定SCM患者与正常患者之间的差异表达基因（DEG）。然后，DEG 用于基因本体论 (GO) 和京都基因和基因组百科全书 (KEGG) 通路富集分析。最后，构建蛋白质-蛋白质相互作用（PPI）网络并使用Cytoscape寻找关键基因。结果。总共鉴定出25个DEG，其中10个上调基因和15个下调基因。这些DEG主要富集在ECM-受体相互作用、扩张型心肌病（DCM）、人乳头瘤病毒感染和粘着斑中，而在GO功能分类中，它们主要富集在细胞外区域、多细胞生物过程的正向调节、建立定位和细胞内囊泡。结论。 7个枢纽基因包括APOE、MFGE8、ALB、APOB、SAA1、A2M和C3，被确定为SCM的枢纽基因，可能用作SCM的诊断生物标志物或治疗的分子靶点。